Ann Infertil Reprod Endocrinol | Volume 1, Issue 2 | Case Report | Open Access
Seda Karabulut1,2*, Elif Yilmaz3, Oya Korkmaz1,2 and Ilknur Keskin1,2
1Department of Histology and Embryology, Istanbul Medipol University, International School of Medicine, Turkey
2Department of Histology and Embryology, Istanbul Medipol University, School of Medicine, REMER (Regenerative and Restorative Medicine Research Center), Turkey
3Medistate Hospital, IVF Center, Turkey
*Correspondance to: Seda Karabulut
Fulltext PDFObjective: The aim of this study was to determine the embryo development rate, embryo quality and cleavage status of the Early Cleaved (EC) and NEC (No Early Cleavage) embryos and to analyze early embryo cleavage as a parameter for embryo selection process after Intracytoplasmic Sperm Injection (ICSI).
Materials and Methods: A total of 184 patients were included in the study. All embryos were checked for early cleavage at 25 hr to 27 hrs post ICSI. Embryo quality and embryo cleavage rates of the EC and NEC embryos were compared. For pregnancy assessment the patients were divided into two groups according to the presence of early cleaved embryos that were transferred. In the first group, all the embryos transferred were EC embryos and in the second group at least one of the embryos was NEC embryos.
Results: Normal embryo development rate (normal blastomere number at the time of embryo transfer) was found significantly higher in the EC embryos than in the NEC embryos (82.9% and 65.6% respectively) (p: 0.001). Embryo qualities were higher in the EC group. Pregnancy rates were significantly higher in the EC group (46.5% and 37.5% respectively).
Conclusion: EC embryos develop more normally, have better quality and have higher pregnancy rates when transferred hence should be used as an important parameter for embryo selection after ICSI.
Embryo selection; Icsi; Multiple pregnancy; Embryo qualit
Karabulut S, Yilmaz E, Korkmaz O, Keskin I. Effects of Early Embryo Cleavage on Embryo Quality and Pregnancy Outcome. Ann Infert Rep Endocrin. 2018;1(2):1010.