Jamsheena P and Sasidharan PK*
Department of Medicine, PVS Hospital Kozhikode, Kerala, IndiaFulltext PDF
Abstract Background: Non-Alcoholic Fatty Liver Disease (NAFLD) has become a leading cause of Chronic Liver Disease (CLD) and a major financial burden on the society. Excess caloric intake, unhealthy diet and physical inactivity remain the main culprits. This study was on management of NAFLD with focus on these precipitating events. Objectives: To study the impact of weight reduction by diet and lifestyle modifications in the management of NAFLD. Methods: A prospective observational single cohort study was conducted over a period of one and a half years. Interview method, a semi structured questionnaire (Proforma) was used to collect data from the subjects. Patients were motivated to reduce weight and educated about healthy eating habits and lifestyle modifications. The effect of weight reduction on serum levels of liver enzymes was assessed by estimating the liver enzyme on follow ups. Results: It was identified that out of 50 study subjects with NAFLD 48 were either overweight or obese. There is a strong association of with weight gain, physical inactivity, consumption of high carbohydrate, high protein diet, intake of junk food, inadequate vegetables and decreased fruits intake. 56% of the study population achieved significant weight reduction sufficient to produce fall in serum SGPT levels by following the advised dietary and physical activity modifications. The association between reduction in weight and the follow up level of serum SGPT was found to be statistically significant (p<0.001). Conclusion: Weight reduction by diet and lifestyle modification normalizes SGPT levels implying that it could prevent NAFLD. There is lack of awareness on hazards of weight gain and lifestyle diseases even among the educated.
Keywords: NASH; NAFLD; Fatty liver; Cirrhosis; Lifestyle; Balanced diet
Jamsheena P, Sasidharan PK. Management of Non-Alcoholic Fatty Liver Disease with Diet and Lifestyle Modification. Ann Clin Med Res. 2020; 1(2): 1009.