Ann Chron Dise | Volume 3, Issue 1 | Review Article | Open Access

Double-Blind Placebo Controlled Study of Thiamine and Cognitive Effect on Chronic Hemodialysis Patients

Isolda Prado de Negreiros Nogueira Maduro1*, Siane Prado Lima Souza2, Alba Regina Jorge Brandão3 and Karla Cristina Petruccelli Israel3

1Department of Nutrition, Amazonas State University, Brazil
2Department of Neurology, Hospital Universitário Getúlio Vargas, Brazil
3Department of Nephrology, Centro de Doenças Renais do Estado do Amazonas, Brazil

*Correspondance to: Isolda Prado de Negreiros Nogueira Maduro 

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Introduction: This study proposed to assess cognitive function against the use of thiamine vs. placebo in patients undergoing Chronic Hemodialysis (CHD) because this group commonly presents risks of losses of vitamins and other nutrients related to dialysis procedure.
Methods: In a double-blind study, 32 patients (12 female/16 male, 55.8 ± 10.10 years) submitted to CHD were recruited underwent collection of blood lactate (changed values above 2.0 mMol/L), Mini-Mental State Exam (MMSE) (changed values score 24 points). Patients were randomly divided into four groups receiving thiamine 300 mg, thiamine 600 mg, placebo and control (no vitamin or placebo), during one month. Excluding those using multivitamins, thiamine or cholinergic replacement therapy, patients with respiratory failure, acute coronary insufficiency, unconscious, pregnancy, and indigenous ethnicity, younger than 18 years. Blood lactate and MMSE were assessed before and after the study. Findings: Thiamine supplementation (300 mg or 600 mg) during one month did not interfere with MMSE in groups or within groups. Groups before vs. after: control group 27.6 ± 1.6 vs. 27.7 ± 1.9 (ns); placebo group 26.7 ± 1.8 vs. 27.0 ± 1.7 (ns); thiamine 300 mg group 27.3 ± 1.1 vs. 27.8 ± 1.6 (ns), thiamine 600 mg group 26.4 ± 1.0 vs. 26.8 ± 1.3 (ns). Moreover, lactate values were not altered during the study.
Discussion: The results suggests no cognitive interfere for patients on chronic hemodialysis with 300 mg or 600 mg of thiamine for 1 month compared with placebo or control groups. Studies with longer duration or the active form of the vitamin should be tested further.


Thiamine; Dialysis; Mini-mental; Cognition; Lactate


de Negreiros Nogueira Maduro IP, Lima Souza SP, Jorge Brandão AR, Petruccelli Israel KC. Double-Blind Placebo Controlled study of Thiamine and Cognitive Effect on Chronic Hemodialysis Patients. Ann Chron Dise. 2020;3(1):1006..

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