Am J Pharmacol | Volume 1, Issue 1 | Review Article | Open Access
Soysa NS1* and Alles NA2
1Department of Oral Medicine and Periodontology, University of Peradeniya, Sri Lanka
2Department of Biochemistry, University of Peradeniya, Sri Lanka
Cell based therapy has become the center of attention in developing novel treatment strategies to many disease conditions. Especially stem cells have gathered much attention due to their selfrenewal ability and clonogenicity. Hematopoitic Stem Cell (HSC) therapy is commonly employed in managing many cancers and conditions involving blood and immune system. With the discovery of mesenchymal stem cells which are found co-localized with HSCs in bone marrow, they have become more popular in past few decades due to their multitude of attractive biological features which make these cells the most attractive cell in regenerative medicine and dentistry. Tissue repair properties, ability to secrete paracrine factor, differentiation ability, immunomodulation and immune-privileged properties make them more amenable to treat many disease conditions like bone diseases, diabetes, strokes, myocardial infarction, etc. Most importantly the ability to isolate these cells from various tissues could overcome the many problems related to cell based therapies.
Soysa NS, Alles NA. Sources of Mesenchymal Stromal Cells: An Overview. Am J Pharmacol. 2018;1(1):1007.