Ann Pulmonary Respir Med | Volume 2, Issue 2 | Research Article | Open Access

Human Herpesviruses Reactivation in COVID-19

Mostafa Alfishawy1, Mahmoud Nassar2*, Hebatallah H Assal3, Ayman K Ibrahim3, Maged S Abdalla3, Nso Nso2 and Amira Elbendary4

1Infectious Diseases, Consultants and Academic Researchers of Egypt IDCARE, Cairo, Egypt
2Icahn School of Medicine at Mount Sinai/NYC H&H Queens, USA
3Misr International Hospital, Giza, Egypt
4Department of Dermatology, Cairo University, Cairo, Egypt

*Correspondance to: Mahmoud Nassar 

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Since the start of the COVID-19 pandemic, a wide range of clinical pictures have been documented ranging from asymptomatic cases to respiratory failure. Accumulating evidence of co-infection and reactivation of viruses during COVID-19 started to emerge. Herein we report three cases of herpes virus reactivation in severely ill COVID-19 patients. With the presence of herpes virus reactivation, one should think for the possibility to screen simultaneously besides SARS-CoV-2 for other respiratory pathogens, not forgetting HSV reactivation, given its similarity in worsening respiratory functions and similarity in radiologic findings to COVID-19. Missing such diagnosis could worsen the clinical course of COVID-19 patients and worsen the prognosis.


Covid-19; Covid; Corona Virus; Coronavirus disease 2019 COVID-19; Human herpesvirus; Pneumonia; Co-Infection; SARS-CoV-2


Alfishawy M, Nassar M, Assal HH, Ibrahim AK, Abdalla MS, Nso N, et al. Human Herpesviruses Reactivation in COVID-19. Ann Pulm Res Med. 2021; 1(1): 1004.

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