Ann Psychiatr Clin Neurosci | Volume 3, Issue 3 | Review Article | Open Access

An Investigation of Headaches in Hypermobile Ehlers- Danlos Syndrome

Amanda R Levy1*, Melvina Nnam1, Mark Gudesblatt2 and Bernadette Riley3

1New York Institute of Technology College of Osteopathic Medicine, USA 2South Shore Neurologic Associates, USA 3Department of Family Medicine, New York Institute of Technology's Ehlers-Danlos Syndrome (EDS)/Hypermobility Treatment Center, USA

*Correspondance to: Amanda R Levy 

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Ehlers-Danlos Syndrome is a group of heritable connective tissue disorder with a variety of subtypes. This review focuses on different types of headache in Hypermobile Ehlers-Danlos Syndrome (hEDS). Although there are various neurological manifestations that could present as headaches in hEDS, this report will discuss the prevalence and presentation of migraine, idiopathic intracranial hypertension, dysautonomia, craniocervical instability, temporomandibular joint dysfunction, and Chiari malformation in patients with hEDS. Although the exact etiology and pathophysiology of various types of headache seen in hEDS is not known. One of the limitations of the study is lack of enough observational studies to establish a causal association between the various types of headache discussed and hEDS. In addition to discussing previous research on these topics, this review summarizes areas in need of further investigation


Levy AR, Nnam M, Gudesblatt M, Riley B. An Investigation of Headaches in Hypermobile Ehlers-Danlos Syndrome. Ann Psychiatr Clin Neurosci. 2020; 3(3): 1034.

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