Francisco S Lozano-Sánchez1,4,5, Angel Muñoz2, José A de las Heras3, Carola Rubio Taboada1,4 and Maria Begoña García-Cenador1,5
1Department of Surgery, University of Salamanca, School of Medicine, Spain
2Service of Otorhinolaryngology, University of Salamanca, School of Medicine, Spain
3Service of Radiology, University of Salamanca, School of Medicine, Spain
4Service of Angiology and Vascular Surgery, University Hospital, Spain
5Salamanca Institute of Biomedical Research (IBSAL), Spain
Carotid paragangliomas are infrequent tumors whose biology and natural history are unpredictable
in a significant number of cases. Such infrequency and the different ways they manifest themselves
pose a diagnostic/therapeutic challenge that is reflected in the final outcomes.
Seventy-five percent of carotid paragangliomas adopt simple forms (single tumors measuring
<4 cm, defined and resectable, non-secretory and benign); with expert treatment, this normal
presentation leads to excellent results. The remaining 25% are complex forms (bilateral, large,
attached to the carotids, functional, malign, associated with other pathologies, etc); morbidity and
mortality rates in these cases are clearly different. Within this complex group, there are a number of
carotid pathologies (e.g., symptomatic stenosis or aneurysms) that are synchronous and ipsilateral
to the paraganglioma.
This review sets out to address these situations in a unitary manner, with its references being very
widely distributed in the literature, with the aim being to highlight their idiosyncrasies of diagnostic
and therapeutic interest. This has involved a systematic literature review of the Medline and
Cochrane Library databases, up to 1 November 2019. This has located 12 articles with a total of 15
Conclusion: Patients with these exceptional combinations are more complex and constitute a
twin challenge: a) diagnostic (search for associations), and b) therapeutic (surgical times and
prioritizations), with the aim being to avoid errors and achieve the best end results.
Carotid body tumor; Carotid paraganglioma; Carotid stenosis; Carotid aneurysm; Carotid endarterectomy; Carotid stent
Lozano-Sánchez FS, Muñoz A, de las Heras JA, Taboada CR, GarcíaCenador MB. Carotid Paraganglioma Synchronous with another Ipsilateral Carotid Disease: A Systematic Literature Review. World J Vasc Surg. 2020;3(1):1020..