World J Surg Surg Res | Volume 5, Issue 1 | Review Article | Open Access

Opioid Free Anesthesia

Onur Koyuncu*, Senem Urfali and Selim Turhanoglu

Department of Anesthesiology and Reanimation, Hatay Mustafa Kemal University, Turkey

*Correspondance to: Onur Koyuncu 

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The first use of opioids in human history dates back to ancient times. It has gained popularity again with the synthesis of synthetic morphine in the last 50 years. Since this date, it has become the primary drug of anesthesia practices. It even led to the emergence of the concept of opioid-based anesthesia; it has become dispensable importance in anesthesia practices. Purposes of getting involved in the practice of anesthesia at the beginning were; a) reducing the consumption of the hypnotic agents, b) inhibiting the activity of the sympathetic system without any histamine release, c) providing effective perioperative analgesia, d) reducing cardiac output with stable coronary perfusion and hemodynamic, e) blocking the ascending nociceptive stimuli. Over the years, as opioids have been used, a large number of undesirable effects have emerged. The main ones are nausea-vomiting, itching, constipation, respiratory depression, hyperalgesia, persistent surgical pain, chronic pain, delirium, immune deficiency, increased hospital stays and associated increased costs.


Opioids; Respiratory depression; Oxycodone


Koyuncu O, Urfali S, Turhanoglu S. Opioid Free Anesthesia. World J Surg Surgical Res. 2022; 5: 1395..

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