Poonam Yadav1*, Niharika Shah2 and Rajendra Kumar Chaudhari3
1B.P. Koirala Institute of Health Science, Nepal 2Department of Pathology, B.P. Koirala Institute of Health Science, Nepal 3Department of Biochemistry, B.P. Koirala Institute of Health Science, NepalFulltext PDF
A serum Thyroid-Stimulating Hormone (TSH) level above the upper limit of normal despite normal levels of serum free thyroxin is known as Subclinical Hypothyroidism (SCH). Various changes in the haemostatic profile have been described in patients with subclinical hypothyroidism. These changes could be encountered as complicating factors in various systemic disorders like cardiovascular disorders, endocrinal disorders. Objective of this study was to evaluate some haemostatic parameter among patients with subclinical hypothyroidism and compare them with healthy individuals and also compare the coagulation profile tests among the subclinical hypothyroid patients on medication and newly diagnosed hypothyroid patients. This study was conducted at immunoassay and hematology lab of BPKIHS from February to May 2017 which included 60 patients with subclinical hypothyroidism (31 of them were newly diagnosed subclinical hypothyroidism patients and 29 were subclinical hypothyroidism under the treatment) and 60 normal individuals as the control group. Platelet count, Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were performed in patients and control samples. A questionnaire was used to obtain patient’s information including as age, gender, duration of diseases, treatment, diet habitat and family history. The participants were orally interviewed after an informed verbal consent was taken. The result showed, in subclinical hypothyroidism the majority were females (90%), aged 46 years to 50 years, more than 50% had family history of the thyroid disease, with disease duration of up to one year in 55% of the cases. About 48% of the patients were under treatment while 52% were newly diagnosed subclinical hypothyroidism with high BMI (overweight 53% and obese 15%). PT value significantly decreased (p0.05) between newly diagnosed and under treatment subclinical hypothyroidism.
Yadav P, Shah N, Chaudhari RK. Assessment of Coagulation Profile among Subclinical Hypothyroid Patients Attending Immunoassay Lab, BPKIHS, Dharan. World J Clin Pathol. 2019;2(1):1007..