World J Breast Cancer Res | Volume 4, Issue 1 | Review Article | Open Access

Elucidating the Clinical-Pathological Factors and Prognosis in Breast Cancer Young Surviving Women who had a Subsequent Pregnant

Ramírez-Torres Nicolás^1*, Hernández-Valencia Marcelino² and Rivas-Ruíz Rodolfo³

¹Service of Oncological Gynecology, UMAE del Hospital de Ginecología y Obstetricia No. 3, National Medical Center (CMN) La Raza, Mexican Institute of Social Security (IMSS), Mexico ²Unit of Medical Research in Endocrine Diseases, Hospital de Especialidades, CMN SXXI, IMSS, Mexico ³Clinical Research Training Center (CAIC), CMN SXXI, IMSS, Mexico

^*Correspondance to: Ramírez-Torres Nicolás 

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Abstract

Objective: To elucidate the impact of clinical-pathological factors on Overall Survival (OS) in patients who got pregnant after breast cancer treatment. Methods: Retrospective cohort of women age younger than 40 years with breast cancer history without active disease at diagnosis of pos cancer pregnancy. Clinical-pathological factors were analyzed by age group and recent birth. Overall Survival (OS) was evaluated from Kaplan-Meier method. The association between clinical-pathological factors and OS was examined using Cox proportional hazards method to estimate Hazard Ratio (HR) with 95% Confidence Intervals (CI). Results: A total of 14 patients were selected. Median age was 28.5 years (inter quartile range, 26-35). Locally advanced stage (IIB-IIIB) was diagnosed in 64.3%. Patients lower than 35 years experienced more positive clinical lymph nodes (72.7%), grade 2 (63.6%) and ER/Pg R-negative tumors (54.5% and 72.7%, respectively). The patients with ER-positive tumors showed an improvement nonsignificant at 5-year OS (87%; p=0.097). In the bivariate analysis, patients with a higher number of pathological lymph nodes (pNs) had a 12% increase in the risk of death than those with lower number (HR=1.12; 95% CI: 1.02 to 1.2). The multivariate model (after adjustment for number of pNs, age and tumor size) as certained that the nodal status was the only independent predictor associated to a worse OS (HR=1.15; 95% CI: 1.01 to 1.3). Conclusion: Pregnancy after cancer did not have a detrimental effect on survival. The patients <35 years old group showed more unfavorable tumor features at diagnosis, which can largely explain a poorer prognosis. Nodal status was the most important prognostic factor that predicted the poor prognosis.

Keywords:

Breast cancer; Young age; Subsequent pregnancy; Postpartum period; Surviving

Citation:

Nicolás R-T, Marcelino H-V, Rodolfo R-R. Elucidating the Clinical- Pathological Factors and Prognosis in Breast Cancer Young Surviving Women who had a Subsequent Pregnant. World J Breast Cancer Res. 2021;4(1):1022..