World J Breast Cancer Res | Volume 2, Issue 2 | Commentary | Open Access

Surgical Wound-Healing and Breast Cancer Progression

Francesca Bianchi and Elda Tagliabue^*

Molecular Targeting Unit, IRCCS Foundation National Cancer Institute (INT), Italy

^*Correspondance to: Elda Tagliabue 

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Abstract

Although surgery remains the most effective treatment for breast cancers, many studies have provided evidence that the wound-healing that follows surgical tissue damage triggers the development of metastases, facilitating the growth of pre-existing micro metastases, enhancing the cancer stem cell population, and thus affecting patient outcomes. One of the strategies that have been adopted to examine the stimulation of the metastatic potential of breast carcinoma cells by wound-healing has been the use of postsurgical drainage that is collected from patients. Perisurgical administration of anti-inflammatory agents, such as Non-steroidal Anti-Inflammatory Drugs (NSAIDs), is being investigated with regard to its ability to slow the protumoral effect of wound-healing

Keywords:

Breast cancer; Wound-healing; Surgery; Metastasis, NSAID

Citation:

Bianchi F, Tagliabue E. Surgical Wound-Healing and Breast Cancer Progression. World J Breast Cancer Res. 2019; 2(2): 1015.