Surg Oncol Clin Pract J | Volume 2, Issue 1 | Research Article | Open Access

Prognostic Value of Preoperative Blood Platelet-toLymphocyte Ratio in Patients Undergoing Surgery for NonSmall Cell Lung Cancer

Jinpeng Li1* and Congcong Shi2

1Department of Surgical Oncology (Interventional Therapy), Shandong Cancer Hospital and Institute, China
2Six Ward Of Shandong Mental Health Center, China

*Correspondance to: Jinpeng L 

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Abstract

Increasing evidence has suggested that the host inflammatory status is associated with prognosis of several solid tumors. Preoperative Platelet- Lymphocyte Ratio (PLR) acquired from routine blood tests, can reflect the status of systematic inflammation. In this study, we aimed to investigate effects of the pretreatment the Platelet to Lymphocyte Ratio (PLR) on the prognosis of Non-Small Cell Lung Cancer (NSCLC) patients after surgical resection.
Methods: Retrospective analysis was performed for 288 cases with histologically confirmed NSCLC that underwent curative resection from April 2009 to June 2012. All patients were classified into two groups based on the median value of PLR. The relationship between PLR and clinicopathological features was studied. Univariate and multivariate analyses were performed to assess the prognostic effect of preoperative PLR.
Results: The median value of preoperative PLR was 142 (range: 45.45 to 272.66). Based on the cutoff value of 142, all patients were divided into two groups: Low PLR (≤ 142, n=145) and high PLR (142, n=143). PLR was correlated with tumor site, T stage, and clinical stage. Five-year survival rates of low and high PLR patients were 49.6% and 33.6%, respectively, which indicated a statistically significant difference (χ2 =6.554, P=0.010) between the two groups. Univariate analysis showed that smoking status, histological differentiation, clinical stage, T stage, N stage, postoperative adjuvant therapy and PLR were associated with survival (P<0.05 for all). Multivariate analysis identified N stage, postoperative adjuvant therapy, and PLR as independent prognostic factors of all the patients. In addition, stratified analysis showed that the five-year survival rate of the low PLR group was higher than that of the high PLR group with or without lymph node metastasis, and the differences were statistically significant (P=0.001 and 0.001).
Conclusion: An elevated blood preoperative PLR indicates poor prognosis in NSCLC patients. Preoperative PLR is an independent prognostic factor of NSCLC after curative resection.

Keywords:

Non-small cell lung cancer; Platelet-to-lymphocyte ratio; Prognosis

Citation:

Li J, Shi C. Prognostic Value of Preoperative Blood Platelet-to Lymphocyte Ratio in Patients Undergoing Surgery for Non-Small Cell Lung Cancer. Surg Oncol Clin Pract J. 2019;2(1):1009.

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