Short Communication

The Chemoprevention and Chemotherapy of Ginger in Prostate Cancer

Chiu-Li Kao1 and Chi-Ming Liu2*
1Department of Nursing, Tzu Hui Institute of Technology, Taiwan
2School of Medicine, Yichun University, China

*Corresponding author: Chi-Ming Liu, School of Medicine, Yichun University, Yuanzhou District, Yichun 336000, Jiangxi, Province, PR China

Published: 15 Jun, 2018
Cite this article as: Kao C-L, Liu C-M. The Chemoprevention and Chemotherapy of Ginger in Prostate Cancer. Ann Pharmacol Pharm. 2018; 3(3): 1150.

Short Communication

Cancer is one of the major causes of death in the world. Prostate cancer is common cancer in western countries. Two types of prostate cancers are defined including hormone-dependent and castration-resistant prostate cancer [1]. Hormone-dependent prostate cancer is sensitive to hormonal therapy and anti-cancer drugs. However, drug resistance and metastasis are often occurred in castration-resistant prostate cancer. Many researchers are searching bioactive compounds from plants for chemoprevention and chemotherapy in prostate cancer [2,3]. Ginger belongs to the Zingiberaceae family. Ginger is popular used as a spice and flavoring agent. During the past decades, a lot of bioactive compounds were extracted, and several in vitro and in vivo studies were investigated in many diseases including cancer prevention, anti-inflammatory and anti-diabetic etc [3]. The mechanism involved in the chemo preventive effects of ginger is contributed by free radical scavenging, anti-oxidant and induction of apoptosis. Several phytochemicals such as gingerols, shogaols, paradols, and gingerdiols have been characterized. 6 - Gingerol is abundant compound in ginger and widely investigated in anticancer studies [4]. 6 - Gingerol can inhibit proliferation or induce apoptosis by disturbing Rb, MAPK, PI3K/Akt, ERK, cell cycle. The other well-known compound is curcumin which is a member of the ginger family, Zingiberaceae. Many studies have indicated curcumin might be a candidate compound for cancer prevention [5]. Studies also shown 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol have anti-cancer activity different types of cancer [4]. Drug resistance in tumor cells is an important issue. Multidrug Resistance (MDR) has been intensively studied and over expression of members of the family of ATP-Binding Cassette (ABC) transporters is indicated [6]. Researchers developed new compounds for inhibiting the activity of ABC transporters and sensitizing classical chemotherapy activity. Recently we indicated that phytochemicals from ginger might display sensitizing the chemotherapy drug activity in chemoresistance prostate cancer cells [7]. Thus gingerols, shogaols, paradols, and gingerdiols can be further investigated the mechanisms with anti-cancer drugs in chemoresistance prostate cancer cells.


  1. Anantharaman A, Friedlander TW. Targeting the androgen receptor in metastatic castrate-resistant prostate cancer: A review. Urol Oncol. 2016;34(8):356-67.
  2. Ding Y, Ren K, Dong H, Song F, Chen J, Guo Y, et al. Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis. Chem Biol Interact. 2017;275:210-7.
  3. Walczak K, Marciniak S, Rajtar G. Cancer chemoprevention - selected molecular mechanisms. Postepy Hig Med Dosw. 2017;71(0):149-61.
  4. Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Gingerols and shogaols: important nutraceutical principles from ginger. Phytochemistry. 2015;117: 554-68.
  5. Qadir MI, Naqvi ST, Muhammad SA. Curcumin: a polyphenol with molecular targets for cancer control. Asian Pac J Cancer Prev. 2016;17(6):2735-9.
  6. Mohammad IS, He W, Yin L. Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR. Biomed Pharmacother. 2018;100:335-48.
  7. Liu CM, Kao CL, Tseng YT, Lo YC, Chen CY. Ginger phytochemicals inhibit cell growth and modulate drug resistance factors in docetaxel resistant prostate cancer cell. Molecules. 2017;22 (9):E1477.