Perspective

Role of Magnesium in Life

Jayesh V Trivedi*
Department Head, Gujarat Adani Institute of Medical Science, India


*Corresponding author: Jayesh V Trivedi, Department Head, Gujarat Adani Institute of Medical Science, India


Published: 17 Feb, 2017
Cite this article as: Trivedi JV. Role of Magnesium in Life. Ann Pharmacol Pharm. 2017; 2(6): 1035.

Abstract

Magnesium deficiency is common but under diagnosed. Treatment of Magnesium deficiency and hypomagnesaemia is beneficial and necessary. Magnesium is the fourth most abundant mineral in body after Calcium, sodium and potassium. About 40% of Magnesium is intra cellular and 60% is present in bone, teeth. Only 1% is available in general Circulation.


Hypomagnesaemia in Adults

It is common in general populations and in aged patient without symptoms. Role of Estrogen is important in its maintenance.


Associated Conditions with Hypomagnesaemia

Hypocalcaemia, Hypokalemia.
Tachyarrythmias, Ventricular tachycardia (Polymorphic), SVT.


Congestive Cardiac Failure, Pregnancy, Lactation

Hypertension
Type 2 Diabetes Mellitus, Metabolic syndrome
Osteoporosis, muscle diseases
Colorectal cancer, Mal-absorption syndrome
Bronchial Asthma, Alcoholism

Diuretics

Hypomagnesaemia may have complains. Concomitant diseases are to be diagnosed. The requirement of daily Magnesium is 320-400mgm per day. Requirement increase in pregnancy and lactation. Green vegetables, cereals, fish and nuts are rich source of Magnesium. Hard water also contains it. Soft water does not contain it. Latent Magnesium deficiency is considered if less than 25 mmol is excreted in 24 hrs urine.
Supplementation of Magnesium is available in chelated and non-chelated forms. Magnesium attached to amino acids have better bioavailability. In normal kidney function hypomagnesaemia does not occur as its gut absorption is reduced and urinary excretion is increased.
Hypomagnesaemia is diagnosed when magnesium level is more than 1.2 mmol/l in blood.
Normal serum Magnesium level does not rule out less stored magnesium. Magnesium loading test is a good tool to diagnose Magnesium deficiency.