Letter to Editor

Responsive and Targeted Drug Delivery Strategies: Success is Far Behind

A K Bajpai*
Department of Pharmacology, Government Autonomous Science College, India


*Corresponding author: A K Bajpai, Department of Pharmacology, Government Autonomous Science College, India


Published: 16 Feb, 2017
Cite this article as: Bajpai AK. Responsive and Targeted Drug Delivery Strategies: Success is Far Behind. Ann Pharmacol Pharm. 2017; 2(5): 1031.

Letter to Editor

The emergence of newer and novel methods of chemical synthesis has provided a new dimension to the existing scenario of pharmacy and medicine. Exploration of new materials with multifunctional properties and performance of small and macro sizes has opened up a new world of research where chemical, pharmaceutical and material sciences have overlapped significantly to design tailor made entities of pharmacological and pharmaceutical importance. In spite of ever seen large number of publications, monographs and patents in medicine and pharmacy, still there are some avenues that need a rigorous innovation and investigations for doing something much better to mankind. In recent times two areas of research have stimulated chemists and pharmacists worldwide, one is responsive drug delivery and the second one is targeted drug delivery. Whereas the former one pertains to the phenomenon of producing a desired and larger change in drug delivery process, the later one is aimed at triggering the drug to a desired target only without disturbing the normal life-style of the patients. Although a long journey of pharmaceutical research has been made in recent decades in the areas of drug delivery systems and technology, yet designing a drug that could respond and target with extreme precision is still a dream.
Till date another significant areas of research that have penetrated into each and every laboratory is nano-science and nanotechnology that have revolutionized the whole domains of pharmacy and medicine. Designing small but versatile nanomaterials like nanoparticles, core-shell nanoparticles, dual responsive nanocarriers, nano-capsules, nanotubes, nano-wires, nano-powders and many more nanostructure assemblies have emerged as excellent options to load, carry and deliver drug and other bioactive molecules (or macromolecules) to a targeted site with optimum efficacy and patients comfort. Not limiting to a particular disease, the nanomaterials science provide endless strategies to fabricate a drug delivery system which could efficiently deliver drugs desirably in terms of dose and location. Whereas making utilization of pH changes along the gastrointestinal tract enable one to design an oral drug delivery formulation for insulin, the measurable difference in temperature and pH between the normal and cancerous cells make it feasible to design nanocarriers like polymersomes that may selectively and specifically target the diseased site sparing normal tissues as much as possible. Another dimension to this kind of targeted drug delivery has been added by synthesis of new and newer type of super-paramegnetic nanomaterials which have already shown promise to carry chemotherapeutic drugs to the tumor sites by simply applying an external magnetic field that dictates the drug molecules to get released in the vicinity of the tumor only and nowhere else.
Apart from these fascinating aspects of drug delivery technologies and systems, there are certain issues that need be paid careful attention. The complex biochemical and physiological profiles of human body, cytotoxicity of the materials, insufficient modeling of the drug release data, mismatching of in vitro and in vivo situations, economical viability, lack of experimentation facilities for in vivo studies, stringent governmental regulations etc. take the things a little bit away from the reality and success. Thus, addressing these and many more such issues is mandatory to bring the research from lab to land.