Volume 1


Review Article

Facile Synthesis of NaMN, NaAD and Derivatives

Simple and efficient syntheses of NAD+, an important biological cofactor, and its precursors have been limited to amido versions.

Published 23 Nov, 2016


Review Article

Research on Peptide Toxins with Antimicrobial Activities

Microbes may quickly acquire resistance to the antibiotics used, since antibiotic agents are now extensively applied in treatment of infectious diseases in clinic.

Published 23 Nov, 2016


Editorial

Small Fish Realm, Big Brain Dream

During the process of drug discovery and development, living animal models have been widely used ranging from lead compound optimization, structure and activity relationship analyses, pharmacokinetic studies, therapeutic evaluation, to toxicity assessment [1,2].

Published 14 Nov, 2016


Research Article

Serotonin-1A Agonist 8-OH-DPAT Alleviates Motor Dysfunction and Motor Neuron Degeneration in a Model of Amyotrophic Lateral Sclerosis

Glutaminergic excitotoxicity, oxidative stress, and inflammation are related to the pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by selective loss of upper and lower motor neurons, progressive paralysis, and muscle atrophy.

Published 14 Nov, 2016


Research Article

Increasing Risk Awareness for Torsades De Pointes: Evaluating QTc-Prolonging Medication use and ECG Monitoring in Hospitalized Patients

Purpose: The objectives of this study were to describe the prevalence of QTc-prolonging medication exposures among hospitalized patients and examine the association between QTc-prolonging medication exposure and new onset QTc-prolongation.

Published 07 Oct, 2016





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