Xinyu Qi, Liang Deng, Fangying Chen and Guohui Li*
Department of Clinical Laboratory, School of Life Sciences, Jiangsu University, ChinaFulltext PDF
Chemo and radiation therapies are the most commonly used therapies for cancer, but they can induce DNA damage resulting in the apoptosis of host cells. DNA Double Strand Breaks (DSBS) are the most lethal form of DNA damage in cells, which are constantly caused by a wide variety of genotoxic agents, both environmentally and endogenously. Meanwhile, eukaryotic organisms have developed a complex mechanism for the repair of DNA damage to maintain genomic integrity. Many cellular biomolecules such as micro RNAs, long non-coding RNAs (LncRNAs), and proteins are involved in the process of DNA repair. In the short communication, we highlight the roles of LncRNAs in regulation of the cellular response to DNA damage and the mechanism of DNA damage repair in cells.
DNA damage response; Repair; Apoptosis; Cell cycle; Cancer; LncRNA
Qi X, Deng L, Chen F, Li G. Roles of LncRNAs in DNA Damage Response and Repair of Cancer Cells. Open J Public Health. 2020;2(2):1013..