Oncol Case Rep J | Volume 4, Issue 3 | Research Article | Open Access

Clinical Spectrum of Gestational Trophoblastic Disease in a Tertiary Care Centre: A Retrospective Analysis

Garima Yadav1, Pratibha Singh1, Arunima Saini1*, Meenakshi Rao2, Priyanka Kathuria1, Meenakshi Gothwal2 and Charu Sharma2

1Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, India 2Department of Pathology, All India Institute of Medical Sciences, India

*Correspondance to: Arunima Saini 

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Objectives: Gestational Trophoblastic Disease (GTD) spectrum includes a wide range of benign and malignant entities associated with abnormal trophoblastic tissue proliferation and hydropic degeneration. In this study, we retrospectively observed all the GTDs in last two and half years at our tertiary care institute and hereby, report our interesting and varied observations of this enigmatic disorder. Material and Methods: All cases with suspected GTD were recruited in our study and divided into Molar group and GTN group after histopathology confirmation. The demographic profile, b-hCG values, WHO scoring and FIGO staging for GTN cases was noted. Results: The total number of cases falling in molar pregnancy group was 6 (60%) while 4 (40%) patients had GTN. The mean age of patients in molar group and GTN group was 25 years and 23 years respectively. Majority (66.7%) of patients in molar group were primipara, while GTN patients were predominantly (75%) nulliparous women. 67% patients of molar patients required blood transfusion. 1/3rd of molar pregnancy patients were detected with hyperthyroidism. The most common presentation in a molar pregnancy was vaginal bleeding in 75% cases, followed by pain abdomen. In GTN group, half the patients did not have any complaint, while another 25% had symptoms due to metastasis like breathlessness, jaundice and vaginal bleeding. Among the molar group, 67% were complete mole and 16% were partial mole. Discussion: In our study, we found a higher ratio of GTN patients at a younger age was noticed in comparison with molar pregnancies (60%:40%; Molar:GTN). Dietary deficiency of beta carotene, nutrients, early age of marriage and first conception, delay in seeking obstetric help contribute to this higher incidence of GTN cases with respect to molar pregnancies. Conclusion: These are treatable gynecological entities requiring proper follow up and timely intervention for preventing life threatening complications.


Complete mole; Gestational Trophoblastic Disease (GTD); Gestational Trophoblastic Neoplasia (GTN); Molar pregnancy; Partial mole


Yadav G, Singh P, Saini A, Rao M, Kathuria P, Gothwal M, et al. Clinical Spectrum of Gestational Trophoblastic Disease in a Tertiary Care Centre: A Retrospective Analysis. Oncol Case Report J. 2021;4(3):1040..

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