Sahara Shurie1, Luhumyo Loice1, Odongo Benjamin Elly1, Emmanuel Wekesa Wamalwa2*, Oyiengo Vincent1, Keitany Kibor Kibet3, Orang’o Elkanah Omenge1 and Muliro Hellen4
1Department of Reproductive Health, Moi University, School of Medicine, Kenya
2Department of Human Pathology, Egerton University, Kenya
3Moi Teaching and Referral Hospital, Kenya
4AMPATH Oncology Institute, Kenya
Background: Cancer of the endometrium is the third most common gynecological cancer after cancer of the cervix and cancer of the ovary in Kenya. It is the most common gynecologic malignancy in the United States. The most common endometrial cancer type is endometrioid adenocarcinoma. It is mostly confined to the uterus and less aggressive. The natural history of epithelial corpus cancer includes 4 potential routes of metastasis: contiguous extension, hematogenous dissemination, lymphatic embolization, and exfoliation with intraperitoneal spread. Case
Presentation: A 45-year-old female, Para 5 + 0, presented to our gynecologic oncology clinic in July 2017. The patient was referred from a peripheral health facility for chemotherapy following radical hysterectomy in May 2017 for endometrial cancer. Histology results of the specimen taken during surgery showed endometrial Ca stage 2, grade 3. The patient developed a swelling on the right leg after completion of 6 cycles of Carboplatin and Paclitaxel. The swelling was progressively increasing in size; reaching 7 cm over a period of 6 months. Biopsy specimen was taken from the swelling and histology showed features consistent with metastatic endometrioid adenocarcinoma.
Conclusion: This is a rare occurrence of distant metastasis of cancer of the endometrium. We recommend histologic evaluation of subcutaneous masses developing in patients with advanced endometrial cancer
Shurie S, Loice L, Elly OB, Wamalwa EW, Vincent O, Kibet KK, et al. Subcutaneous Metastasis of Cancer of the Endometrium: Case Report. Oncol Case Report J. 2019;2(1):1008.