Scott M Belliston1*, Richard M Dubinsky2 and Sharon G Lynch2
1Department of Neurology, Intermountain Healthcare, USA
2Department of Neurology, University of Kansas Medical Center, USA
Objective: To evaluate the risk of cerebrovascular comorbidities in Multiple Sclerosis (MS) in the US.
Methods: A retrospective cohort analysis from 1988 to 2012 of the Nationwide Inpatient Sample. Records were identified with a primary diagnosis of cerebrovascular disease (ischemic stroke, hemorrhagic stroke and non-ruptured aneurysm) and a secondary diagnosis of MS. Prevalence of MS in this cohort versus the general population was compared using indirect adjustment. We calculated the Standardized Prevalence Ratio (SPR), adjusted for sex and age.
Results: Among 2,574,503 admissions for cerebrovascular events, 0.18% had MS. When corrected to age and gender and the SPR of MS among patients with ischemic stroke was 1.6218 (95% confidence interval [CI] 1.6188, 1.6249); for hemorrhagic stroke 1.3030 (1.2966, 1.3095); and unruptured aneurysm was 3.2359 (3.1943, 3.2781).
Conclusion: In this national US hospital cohort, the prevalence of MS in the population with cerebrovascular events was overrepresented, suggesting that MS may increase the risk for cerebrovascular events.
Multiple sclerosis; Stroke; Ischemic stroke; Hemorrhagic stroke; Aneurysm
Belliston SM, Dubinsky RM, Lynch SG. Cerebrovascular Comorbidities in Multiple Sclerosis: Analysis of the Nationwide Inpatient Sample. Neurol Disord Stroke Int. 2018; 1(2): 1012.