Neurol Disord Stroke Int | Volume 1, Issue 1 | Research Article | Open Access

Association of Serum 25-hydroxyvitamin D in Multiple Sclerosis: A Study from South India

Jaydip Ray Chaudhuri1, Kandadai Rukmini Mridula2, Matapathi Umamahesh3, Banda Balaraju4 and VCS Srinivasara Bandaru1,5*

1Department of Neurology, Yashoda Hospital, India
2Department of Neurology, Nizam’s Institution of Medical Sciences, India
3Department of Radiology, Yashoda Hospital, India
4Department of Medicine, Yashoda Hospital, India
5Department of Clinical Research, Yashoda Hospital, India

*Correspondance to: VCS Srinivasarao Bandaru 

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Studies have incriminated vitamin D deficiency to be associated with Multiple Sclerosis (MS). To investigate association between serum 25-hydroxyvitamin D and MS.
Methods: We recruited 56 MS patients and 56 age and sex matched controls from Yashoda hospital, study period from August 2011 to July 2016. All cases and controls were evaluated for various risk factors and underwent tests for serum 25-hydroxyvitamin D, lipid profile estimation. Expanded Disability Status Scale (EDSS) was assessed in cases and dichotomized to low (≤ 3) and high (≥ 3.5) impairment.
Results: Out of 56 patients, men were 28 (50%), serum 25-hydroxvitamin D deficiency was significantly higher in cases 39 (76.4%) compared to controls 14 (27.4%) (p < 0.0001). Mean total cholesterol, mean triglycerides (p<0.0001) and mean Low-Density Lipoprotein (LDL) (p=0.03) levels were significantly higher, while mean High-Density Lipoprotein (HDL) levels were significantly lower in cases. Among MS subtypes, 25-hydroxyvitamin D deficiency found 33(84.6%) in Relapsing-Remitting MS (RRMS), 3(7.6%) in Secondary-Progressive MS (SPMS) and 3(7.6%) in Clinically Isolated Syndrome (CIS).Elevated mean total cholesterol, LDL, mean triglycerides levels, low mean HDL and high EDSS were significantly associated with 25-hydroxyvitamin D deficiency in cases (p = 0.01). After adjustment using multiple logistic regression analysis, serum 25-hydroxyvitamin D deficiency an independent association with MS (Odds: 2.5:95% CI: 1.1-5.2) and high EDSS (Odds: 3.5: 95% CI: 2.1-18.4).
Conclusion: In our study, we found serum 25-hydroxyvitamin D deficiency an independently associated with MS and high EDSS.


Serum 25-hydroxyvitamin D; MS subtypes; RRMS; SPMS; CIS; EDSS; Dyslipidemia; Indian study


Chaudhuri JR, Mridula KR, Umamahesh M, Balaraju B. Srinivasara Bandaru VCS. Association of Serum 25-hydroxyvitamin D in Multiple Sclerosis: A Study from South India. Neurol Disord Stroke Int. 2018; 1(1): 1006.

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