J Respir Med Lung Dis | Volume 4, Issue 1 | Review Article | Open Access

The Expression of Glucocorticoid Receptor in Patients with Small Cell Lung Cancer with or Without Ectopic Adrenocorticotropic Hormone Syndrome

Xiaobo Wang¹, Jing Ke¹, Zongwei Wang¹, Ying Feng¹, Mingzhu Hu², Nannan Wu¹ and Dong Zhao^1*

¹Department of Endocrinology, Capital Medical University, China
²Department of Pathology, Capital Medical University, China

^*Correspondance to: Dong Zhao 

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Abstract

Purpose: Ectopic Adrenocorticotropic Hormone (ACTH)-secreting syndrome (EAS) is a relatively rare disease. EAS could not be inhibited by endogenous or exogenous glucocorticoid, which may be its most important characteristic. We guess the difference of Glucocorticoid Receptor (GR) expression may be the reason of no response to exogenous glucocorticoid in EAS. Therefore, we aimed to explore the difference in the expression of GR in Small Cell Lung Cancer (SCLC) with or without EAS.Methods: In this study, we first report one patient with EAS caused by SCLC, and we examined ACTH and GR expression of pulmonary tissue as positive control, and then we examined the ACTH and GR expression in SCLC patients with or without EAS.
Result: Immunochemistry analysis showed that there is no obvious difference in the expression of GR in SCLC without EAS compared with normal people. While in the EAS patient, GR expression was absent in the tissue.Conclusion: Therefore, our study revealed the difference of GR expression in Small Cell Lung Cancer (SCLC) with or without EAS.

Keywords:

Small cell lung cancer; Ectopic ACTH syndrome; Glucocorticoid receptor

Citation:

Wang X, Ke J, Wang Z, Feng Y, Hu M, Wu N, et al. The Expression of Glucocorticoid Receptor in Patients with Small Cell Lung Cancer with or Without Ectopic Adrenocorticotropic Hormone Syndrome. J Respir Med Lung Dis. 2019; 4(1): 1041.