J Res Notes | Volume 1, Issue 1 | Research Article | Open Access

Evaluation of Immunomodulatory Activity of Protocatechuic Acid

Amruta Rasne¹, Vivek Sonwane^1*, Rahul Somani² and Prashant Kumthekar³

¹Department of Pharmacology, AISSMS College of Pharmacy, India
²Alkem Laboratories, India
³Bio Scientific Research Laboratories, India

^*Correspondance to: Vivek Sonwane 

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Abstract

Several drugs such as anti-cancer drugs and important antibiotics such as linezolid pose the serious disadvantage of causing myelosuppression. Cyclophosphamide, a known anti neoplastic agent of the alkylation class suppresses T-lymphocyte activity, leading to a suppressed immune function. It is used experimentally to mimic an immunodeficient condition. Protocatechuic acid is water soluble monomeric phenolic acid with strong free radical scavenging effects. The immunity system play main role in protection of body from infection. The system is divided into two major types. • Innate immune system • Adaptive immune system Rational behind this study was to investigate Protocatechuic Acid for its Immunomodulatory activity in laboratory animals using different preclinical screening models and Antibody molecules secreted by plasma cells mediate humoral response, increase in Hemagulation indicates immunostimulant activity. Different groups of animals receiving PCA at 10 mg/kg, 30 mg/kg, and 100 mg/kg, and of the normal control group that did not receive cyclophosphamide indicating that PCA restored the TLC back to the baseline values. The evaluation parameters are Haemagglutinating Antibody (HA) titre value. Neutrophil adhesion test Delayed Hypersensitivity reaction (DTH). The estimation of study parameter here we can conclude that the highest dosed animals i.e. 100 mg/kg shown significant effect.

Keywords:

Immunomodulatory; Protocatechuic acid; Cyclophosphamide

Citation:

Rasne A, Sonwane V, Somani R, Kumthekar P. Evaluation of Immunomodulatory Activity of Protocatechuic Acid. J Res Notes. 2018;1(1):1007.