J Gynecol Oncol | Volume 3, Issue 3 | Case Report | Open Access

Advanced Pelvic Malignancy Causes Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Case Report

Xiaolin L¹, Fenge L^1,2, Yumei Z¹, Jing L¹, Zhonge T¹ and Quanxin Q^1*

¹Department of Gynecology, Tianjin First Central Hospital, China
²Department of Melanoma Medical Oncology Research, University of Texas M.D. Anderson Cancer Center, USA

^*Correspondance to: Quanxin Qu 

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Abstract

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is defined as an array of clinical syndromes resulting from improper secretion of endogenous diuretic hormone or renal hypersensitivity to Antidiuretic Hormone (ADH). The cardinal feature for SIADH is hyponatremia, which represents a prognostic factor correlated with survival in cancer patient. SIADH has been closely linked with cancer, including small cell lung cancer, leukemia ureteral and prostate carcinoma, and bladder carcinoma. Here, we present a first case report of SIADH caused by advanced pelvic malignant tumor. The patients with persistent hyponatremia, although we conducted hypertonic saline treatment and chemotherapy to reduce tumor burden, the patient failed to respond and died within 17 days since hospital admission. This case suggests pelvic malignant tumors as a cause for SIADH, and prompt diagnose and accurate treatment is crucial for patient survival.

Keywords:

SIADH; Pelvic Malignant tumor; Hyponatremia; Survival

Citation:

Xiaolin L, Fenge L, Yumei Z, Jing L, Zhonge T, Quanxin Q. Advanced Pelvic Malignancy Causes Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Case Report. J Gynecol Oncol. 2020; 3(3): 1034.