J Gynecol Oncol | Volume 2, Issue 3 | Research Article | Open Access

The Impact of Endometrial Hyperplasia without Atypia on In Vitro Fertilization Outcome

Levakov SA1, Blinova EV2,3, Lukianova IS1, Kudriavtzev MJ1, Tumutolova OM3, Blinov DS4* and Makarkina VN5

1Department of Obstetrics and Gynecology, Sechenov University, Russia 2Department of Clinical Anatomy, Sechenov University, Russia 3Department of Obstetrics and Gynecology, National Research Mordovia State University, Russia 4Laboratory of Molecular Pharmacology, All-Union Research Center for Biological Active Compounds Safety, Russia 5Department of Fundamental Medicine, Lomonosov Moscow State University, Russia

*Correspondance to: Blinov DS 

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Context: A role of endometrial hyperplasia in efficacy of assisted reproductive technology remains unclear as do involvement of local antioxidant defense system and vitamin D serum level. Aim: To determine whether endometrial hyperplasia without atypia impacts in vitro fertilization outcome as well as highlight a role of local antioxidant defense system and 25-hydroxicalciferol serum level as possible markers for ART efficacy in infertile women with endometrial hyperplasia. Setting and design: Two-stage observational non-interventional study with 2000 clinical cases analyzed during retrospective stage and 250 participants on prospective stage. Materials and methods: Pregnancy rate was assessed to determine an influence of endometrial hyperplasia without atypia on in vitro fertilization outcome. Local antioxidant defense level was registered by superoxide-dismutase activity detection and total antioxidant capacity measurement in endometrial tissue prior to embryo transplantation. 25-hydroxicalciferole serum concentration was determined by quantitative enzyme-linked immunosorbent assay method. Statistical analysis used: We applied “Chi-square” criterion to comparatively assess the in vitro fertilization outcome. The normality of the variance distribution was determined using one-way Analysis of Variance (ANOVA), while Newman-Keuls criterion was used to intergroup assessment. Results: Pregnancy rate among women with endometrial hyperplasia without atypia undergone in vitro fertilization was lower than in control group largely due to results obtained in subgroup of women older than 40. Negative outcome associates with depletion of antioxidant system potency in hyperplastic endometrium and decrease of vitamin D serum level. Conclusion: Superoxide-dismutase activity in endometrial tissue and local total antioxidant capacity along with vitamin D serum level may be considered as potential biomarkers of fertilization outcome in endometrial hyperplasia without atypia.


In vitro fertilization outcome; Endometrial hyperplasia without atypia; Superoxidedismutase; Total antioxidant capacity; 25 hydroxicalciferol


Levakov SA, Blinova EV, Lukianova IS, Kudriavtzev MJ, Tumutolova OM, Blinov DS, et al. The Impact of Endometrial Hyperplasia without Atypia on In Vitro Fertilization Outcome. J Gynecol Oncol. 2019; 2(3): 1019.

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