J Gynecol Oncol | Volume 2, Issue 2 | Research Article | Open Access
Amina Mokrani, Wafa Sbika*, Yosra Yahyaoui, Azza Gabsi, Fahmi Mghirbi, Feriel Letaif, Khedija Meddeb, Mouna Ayadi, Nesrine Chraiet, Henda Raies and Amel Mezlini
Department of Medical Oncology, University of Tunis EL Manar, Tunisia
*Correspondance to: Wafa Sbika
Fulltext PDFBackground: Malignant Ovarian Germ Cell Tumors (MOGCTs) are rare and accounts for 2% to 3% of ovarian malignancies. The aim of this study was to describe characteristics in patients with MOGCTs and to analyze the treatment outcomes. Methods: This was a retrospective study about 92 patients with MOGCTs treated in Salah Azaiez Institute in Tunisia between 1984 and 2012. Results: The median age of diagnosis was 26 years (range, 8-76). The main clinical features were abdominal pain (81%) and abdominal distension (59%). Physical examination revealed an abdominal or pelvic mass in 68% of cases. The pathologic diagnoses were dysgerminoma in 29 patients, immature teratoma in 32, yolk sac tumor in 13, and mixed germ cell tumor in 12, embryonal carcinoma in 3 and choriocarcinoma in 3 patients. The majority presented with earlystage (I/II) disease (77%). Fifty eight patients (63%) underwent primary conservative surgery and 56% of patients were treated with cisplatin based chemotherapy. Six patients received adjuvant radiotherapy. The median follow-up period was 74 months (range 7 to 182). There were 13 cases of recurrence. The median time to relapse was 12 months (range 1 to 32). There were 8 cases of distant metastasis. The 5-year overall and disease-free survivals were 78% and 82%. Prognostic factors were age, stage, tumor size, optimal surgery and adjuvant chemotherapy. Four spontaneous pregnancies were achieved. Conclusion: The Prognosis is closely related to disease stage. Fertility sparing surgery should be considered in early-staged young patients.
Ovarian neoplasm; Germ cell and embryonal neoplasms; Surgery; Chemotherapy; Prognosis
Mokrani A, Sbika W, Yahyaoui Y, Gabsi A, Mghirbi F, Letaif F, et al. Clinical Characteristics and Treatment Outcomes of Patients with Malignant Ovarian Germ Cell Tumors: A Retrospective Monocentric Study. J Gynecol Oncol. 2019; 2(2): 1014.