J Forensic Sci Toxicol | Volume 3, Issue 1 | Review Article | Open Access
Suhayr A Alqaysi*, Thana Mohammed Juda, Seenaa Badr Mohammed, Zinah Abbass Ali and Hiba Resheed Behayaa
Department of Medical Physiology, University of Babylon, Iraq
*Correspondance to: Suhayr A Alqaysi
Fulltext PDF"MYH9 gene" is "expressed" in "kidney, platelets and liver and in lesser amounts in the thymus, spleen, and intestine", it’s responsible for encoding a protein called" non muscle myosin heavy chain". Very specialized cells which are podocytes, it’s capable to ultra filter blood and support "glomerular capillary pressures" due to this function, the expression of "non-muscle myosin heavy chain" inside it. Disturbed and irregularity in MYH9 gene expression, or change in its positioning, or task cause "cytoskeleton damage, causing proteinuria: hematuria which may predispose chronic renal impairment and even "renal failure". Renal failure is the result of a sequent of different illnesses and accidents that affect directly or indirectly on the renal system. Kidney which has a vital charisma in regulating many body functions, so its deterioration leads to the deterioration of the whole human body. Renal failure is considered incurable and need hard-hitting ways to avoid it or to compensate the function of the kidney. Objective: To evaluate the role of MYH9 SNP on developing of renal failure. This study depending on "methodology of Case-control study", subjects involved were one hundred as patients and control; 50 "patients" complaining renal failure who attended dialysis Centre in Marjan Medical City in Hilla, Iraq and 50 apparently healthy controls. DNA was extracted from venous blood. The "MYH9 gene polymorphisms" were recognized by applying the procedure of ("PCR-RFLP"). Data analyses perform using "SPSS". Genotype at rs4821480 in patients with RF: finding that obtained were TT (59%), GT (34%), and GG (6.0%) and for control TT (45%) GT (40%), GG (15%). This analysis of data indicated the TT genotype homozygote at rs4821480 convenes independently a threating of RF than does the GT and GG genotypes. A variation in the genotype at rs3752462 was shown in patients with RF: CC (4.8%), CT (73.2%), and TT (22.0%). The outcomes indicate that the CT genotype at rs3752462 confers independently a risk factor of RF than those of TT and CC genotypes. There is no significant correlation between distribution of alleles and age, sex, resident, jobs, smoking habit, family history, Body Mass Index (BMI), and medical history (P>0.05). From this study concluded the MYH9 SNP genotyping aid to notice individuals at risk for developing renal function deterioration.
MYH9 SNP; Renal failure; Allele distribution and genotyping
Alqaysi SA, Juda TM, Mohammed SB, Ali ZA, Behayaa HR. Genetics Risk Factors and Progression of Renal Failure. J Forensic Sci Toxicol. 2020; 3(1): 1012.