J Dent Oral Biol | Volume 2, Issue 9 | Short Communication | Open Access

Intraarticular Injections Experimentally Induced Osteoarthritis in Rat Temporomandibular Joint

Mehmet Yaltirik1*, Alen Palancioğlu1, Karolin Yanar2 and Cevat Tuğrul Turgut1

1Department of Oral and Maxillofacial Surgery, Istanbul University, Istanbul, Turkey
2Department of Medical Biochemistry, Istanbul University Cerrahpaşa Faculty of Medicine, Istanbul, Turkey

*Correspondance to: Mehmet Yaltirik 

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Abstract

This study is to investigate the changes of Temporomandibular Joint (TMJ) by experimentally induced osteoarthritis (OA) and to compare effectiveness of intraarticular injections. Intraarticular Monosodium Iodoacetate (MIA) solution was injected bilaterally to experimental groups to induce TMJ osteoarthritis. 0•9% NaCl solution was injected to TMJ of healthy control group bilaterally to investigate the effect of trauma by intraarticular injection. For treatment group were injected intraarticularly with Hyaluronic Acid (HA), second subgroup with Dexamethasone (DEX) and third subgroup with Botulinum Toxin A (BTX A). Groups treated with HA and DEX showed statistically significant healing compared with untreated MIA group.

Keywords:

Osteoarthritis; Monosodium iodoacetate

Citation:

Yaltirik M, Palancioğlu A, Yanar K, Turgut CT. Intraarticular Injections Experimentally Induced Osteoarthritis in Rat Temporomandibular Joint. J Dent Oral Biol. 2017; 2(9): 1062.

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