J Clin Obstet Gynecol Infertil | Volume 1, Issue 4 | Case Report | Open Access

Infants Born to HBV Genotype A-Carrier Mothers have Begun to Appear in Japan

Masachi Hanaoka¹, Michi Hisano¹, Keiko Tsukamoto¹, Reiko Ito², Yushi Ito¹, Haruhiko Sago¹, Akira Matsui² and Koushi Yamaguchi^1*

¹Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan
²Depertment of General Medicine, National Center for Child Health and Development, Tokyo, Japan

^*Correspondance to: Koushi Yamaguchi 

Fulltext PDF

Abstract

Acute hepatitis by hepatitis B virus (HBV) genotype A causes long duration of hepatitis, and the carrier rate after acute infection is approximately 10%. The genotype A hepatitis has become the most common acute infection linked to horizontal transmission among young people in recent years. Increases in HBV genotype A-carrier mothers are expected in the near future in Japan, and prophylaxis against mother-to-child transmission for hepatitis B virus genotype A-carrier mothers will therefore be important in suppressing expansion of this viral infection. This report describes that infants born to HBV genotype A-carrier mothers have begun to appear in Japan and prevention of mother-to-child transmission (MTCT) was performed by administration of immunoglobulin derived from genotype A virus antigen with subsequent inoculation of vaccine derived from genotype C virus antigen.

Keywords:

Hepatitis B virus genotype A; Mother-to-child transmission; HBV immunoglobulin; HBV vaccine

Citation:

Hanaoka M, Hisano M, Tsukamoto K, Ito R, Ito Y, Sago H, et al. Infants Born to HBV Genotype A-Carrier Mothers have Begun to Appear in Japan. J Clin Obstet Gynecol Infertil. 2017; 1(4): 1021.