J Clin Nephrol Kidney Dis | Volume 2, Issue 1 | Case Report | Open Access

A Case of Clinical Transformation between C3 Glomerulonephritis and Atypical HUS

Faizan Babar^1*, Scott Cohen¹ and Eric Brown²

¹Department of Nephrology, George Washington University, Washington DC, USA
²Mid-Atlantic Nephrology Associates, Glen Burnie, Maryland, USA

^*Correspondance to: Faizan Babar 

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Abstract

The clinical and pathological approach to (MPGN) has evolved in recent years. Traditionally classified into types I, II, and III MPGN based on electron microscopic findings, MPGN is now being classified by immunofluorescence microscopy. This shift in classification aims to define MPGN by the underlying pathogenic process as opposed to the histologic appearance alone, which was flawed due to significant overlap among the different types [1]. Currently, the bulk of MPGN is designated either as an immune-complex-mediated lesion or a lesion due to persistent activation of the alternative complement pathway, though MPGN caused by direct endothelial injury has also been described [2]. In the following case, we present a patient with complement-mediated MPGN, defined ultra-structurally as C3GN, who went on to develop aHUS.

Keywords:

C3 glomerulonephritis; Atypical HUS

Citation:

Babar F, Cohen S, Brown E. A Case of Clinical Transformation between C3 Glomerulonephritis and Atypical HUS. J Clin Nephrol Kidney Dis. 2017; 2(1): 1010.