Yann Gricourt1, Thierry Boudemaghe2, Mamadou Balde2, Amal Boussère2, Natacha Simon1, Xavier Capdevila3, Jean Yves Lefrant1, Philippe Cuvillon1* and Thibault Mura2
1Division of Anesthesia Intensive Care, Pain and Emergency Medicine, Nîmes University Hospital, France
2Department of Biostatistics, Epidemiology, Public Health and Methodological innovation (BESPIM), Nîmes University Hospital, University Montpellier 1, France
3Division of Anesthesia Intensive Care, Pain and Emergency Medicine, Montpellier University Hospital, Montpellier, France and Inserm Unit 1298 Montpellier Neuro Sciences Institute, Montpellier University, France
Background: Although COVID-19 and major surgery have been linked to mortality, controversy exists about the risk of higher mortality in the context of hip fracture. The objective of this study was to assess the association between mortality (30th day postoperatively) and hip fracture surgery in patients with COVID (PCR+ 30 days) before surgery. Methods: This was a population-based, retrospective cohort study of adults undergoing hip fracture surgery between March 1st and December 31st, 2020, at private or public hospitals in France. Patients were adults, >65 yrs, with hip fracture admitted for surgery. SARS-CoV-2 infection within 30 days before surgery was recorded. Main outcome was mortality within 30 days after surgery. Secondary outcomes included univariate and multivariate analysis of the association between subject characteristics and death at 30 days. Results: Among 73,661 patients with hip fracture (mean age 85 ± 7.9 yrs, 76% women) who met study entry criteria, overall mortality at 30 days was 4.8%. Among them, mortality in non-COVID patient was recorded for 3 304 (4.58%). For patients with SARS-CoV-2 infection (1,505 patients), mortality was recorded for 228 (15.15%; p(Khi-2) <0.0001. The pair hip fracture and COVID-19 were associated with higher risk of mortality: OR, 3.72; 95% CI, 3.21-4.30; P<00.1. Conclusion: Among adults undergoing hip fracture surgery, COVID-19 infection was associated with a greater risk of 30-day mortality.
Gricourt Y, Boudemaghe T, Balde M, Boussère A, Simon N, Capdevila X, et al. Association between COVID-19 Disease and Mortality after Hip Fracture Surgery in Elderly: A Multicentre National French Survey. Clin Surg. 2022; 7: 3485..