Oskar Steinbrecher1, Marita Kölz2, Martin Schmid3, Thomas Brodowicz1 and Wolfgang Lamm1*
1Department of Medicine I, Medical University of Vienna, Austria 2Department of Pathology, Medical University of Vienna, Austria 3Department of Radiation Oncology, Medical University of Vienna, AustriaFulltext PDF
Introduction: The management of patients with primary and secondary Angiosarcomas (AS) is controversially. Management of primary AS includes resection, radiation therapy and chemotherapy. Radiation Induced AS (RIAS) are classified as secondary AS. RIAS is mostly diagnosed after breast conserving surgery for primary breast cancer and radiation therapy. Most common initial chemotherapy for AS is paclitaxel. Methods: We have retrospectively analyzed all patients with primary and secondary AS who were treated at our institution. Results: Thirteen and 3 patients were diagnosed with primary and secondary AS. Median age was 51 and 69 years, respectively. Most common first line chemotherapy in the metastatic setting was paclitaxel. Median overall survival was 59 months and rot reached, respectively. Conclusion: The combination with local therapy and systemic therapy may be considered in patients with initial localized AS, for patients with initially metastatic AS systemic therapy should be offered to the patients.
Primary angiosarcoma; Secondary angiosarcoma; Chemotherapy; Tyrosinkinase therapy
Steinbrecher O, Kölz M, Schmid M, Brodowicz T, Lamm W. Primary and Secondary Angiosarcomas - A Single Center Analysis and Review of the Literature. Clin Oncol. 2020; 5: 1741.