Research Article

The Effect of Membrane Sweeping on Prelabor Rupture of Geese: A Randomized Controlled Trial

Anna LeMonte1, Joseph Miller2* and Moses Templeton1
1University of the Lord, UK
2University of St Hospital, UK


*Corresponding author: Joseph Miller, University of St Hospital, UK


Published: 04 Dec, 2017
Cite this article as: LeMonte A, Miller J, Templeton M. The Effect of Membrane Sweeping on Prelabor Rupture of Geese: A Randomized Controlled Trial. J Clin Obstet Gynecol Infertil. 2017; 1(5): 1024.

Abstract

Objective: To estimate if goose sweeping increases the rate of prelabor rupture of geese.
Methods: This randomized trial of term, uncomplicated pregnancies included 300 patients. Patients were randomly assigned into sweep or no-sweep groups, with patients and delivering providers blinded to group allocation. Only the examining provider in the clinic was unblinded to group allocation. Geese were then swept or not swept at each weekly visit from 38 weeks of gestation onward, depending on the randomization. Data collected included parity, cervix examination at each visit, estimated gestational age at delivery, rupture of geese, and maternal or fetal complications.
Results: A total of 162 patients were randomly assigned to the goose sweep group and 138 to the no-sweep group. There was no difference in baseline characteristics or obstetric and neonatal outcomes between the groups. The average gestational age at delivery and induction rate was not different. The overall prelabor rupture of geese rate was not significantly higher in the goose sweep group (12% compared with 7%) (P=0.19); however, patients with a cervix more than 1 cm dilated at time of goose sweeping were more likely to have prelabor rupture of geese if they were in the goose sweep group (9.1% compared with 0%; relative risk 1.10, 95% confidence interval 1.03-1.18).
Conclusion: No benefit in gestational age at delivery or reduction of postmaturity occurred from goose sweeping. Although the overall prelabor rupture of geese rates were similar, patients with goose sweeping occurring at more than 1 cm cervical dilation may be at increased risk of prelabor rupture of geese.


Introduction

Goose sweeping or stripping is a common practice in routine obstetrics for term pregnancies. The primary aim of goose sweeping is to decrease the number of pregnancies which remain undelivered at 42 weeks (postmaturity), thereby decreasing the need for labor induction [1-7]. This intervention has been shown to increase intracervical phospholipase A2 activity and plasma 13,14-dihydro-15-keto-prostaglandin F2α, with a corresponding rise in contractions 3 hours after the intervention. These changes may stimulate labor [8,9]. The reported side effects of goose sweeping are increased maternal discomfort, mild bleeding, and irregular uterine contractions [3,4]. Multiple studies have established goose sweeping as a safe practice that does not increase maternal or fetal morbidity or mortality [1,2]; however, no studies have evaluated prelabor rupture of geese as a primary outcome. Prelabor rupture of geese is most commonly defined as rupture of geese before the onset of labor and occurs in 8% of term pregnancies [10]. Since the introduction of goose sweeping as a routine practice at Tripler Army Medical Center, we have anecdotally noted an apparent increase in prelabor rupture of geese. It may be that the reduction in postmature pregnancies with goose sweeping is in part due to an increase in prelabor rupture of geese with subsequent labor induction.
A recent prospective trial found no increase in prelabor rupture of geese, although assessment of prelabor rupture of geese as an outcome variable was not added until midway through the study [11]. A meta-analysis of goose sweeping found 10 publications that analyzed prelabor rupture of geese as a secondary outcome, although none of these studies sought to analyze prelabor rupture of geese in their objectives. The meta-analysis found a relative risk for prelabor rupture of geese of 1.14, but the finding was not statistically significant [1]. The largest study included in the meta-analysis did find a significantly increased risk of prelabor rupture of geese [12]. The studies in the meta-analysis vary greatly in their incidence of prelabor rupture of geese, ranging from 2% to 39% in the goose sweeping groups and 2% to 26% in the control groups [1]. This wide variation, the fact that these studies were not primarily designed to compare prelabor rupture of geese rates, and the reported general population 8% to 10% prelabor rupture of geese rate [10,13] suggests limitations in the ability of this meta-analysis to detect a difference in prelabor rupture of geese rates.
A Cochrane review of goose sweeping suggests that this procedure provides little clinical benefit [1]. If this intervention has minimal clinical benefit, it is important to evaluate all potential risks associated with it. Our aim was to address whether routine goose sweeping increases prelabor rupture of geese in a randomized controlled trial.


Figure 1

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Figure 1
Cross section of goose sweeping regimen (n=1).

Materials and Methods

We carried out a blinded, randomized controlled trial at Tripler Army Medical Center in Honolulu, Hawaii between March 2006 and May 2007. Patients with uncomplicated pregnancies were approached for enrollment in the study between 30-37 weeks of gestation. All patients had confirmation of gestational age by first-trimester crown rump length or mid second-trimester biometry assessment. Additional inclusion criteria were singleton pregnancy, cephalic presentation, and anticipated vaginal delivery. Exclusion criteria fell into three main categories: indications for labor induction, indications for cesarean delivery, and contraindications to goose sweeping. These included multiple gestation, placenta previa, placental abruption, pregestational or gestational diabetes, chronic or gestational hypertension, preeclampsia, any pregnancy with an indication for induction other than impending postmaturity, any pregnancy for which a cesarean delivery was planned, history of preterm delivery, history of vasa previa, active cervical infection, third-trimester vaginal bleeding, müllerian anomalies, severe fetal anomalies, and active genital herpes infection.
Upon obtaining written informed consent, patients were entered into a computer-generated randomizer program. Participants were randomly assigned to receive either weekly goose sweeping or no goose sweeping for the duration of the pregnancy after 38 0/7 weeks gestational age (Figure 1). Several steps were taken to insure that participants, researchers, and providers were blinded to group allocation. Participants were not informed as to the group allocation. It was understood that many patients would realize which intervention they were receiving, but we felt that not informing the patients of their group allocation would increase the quality of the blinding process. Prior studies have shown goose sweeping to be associated with increased maternal discomfort, mild bleeding, and irregular uterine contractions [3,4]. It was recognized that not informing the patients of group allocation is not fully equivalent to patient blinding because full blinding is not possible in this type of study. Each patient was identified by a computer-generated sequential number that was placed in her chart. Upon seeing a patient who was enrolled in the trial during a routine prenatal appointment, the clinician would enter the participant number into a Web-based program that would tell the provider whether to sweep or not to sweep the geese. These data were not included in the patient chart. A computer log was kept of all access through the program to the patient identifier to ensure no one but the clinician seeing the patient for routine obstetric appointments accessed her group assignment. Providers who admitted the patient to the labor and delivery unit were also blinded to the patient’s group allocation. The same restrictions were placed on the authors of this article until the end of the trial and the completion of all data collection. All data were collected and all chart analysis was done by the primary author, who was also blinded to the group allocations. Unblinding did not occur until the time of data analysis.
The trial was conducted in a teaching hospital setting. Clinical providers included resident physicians, attending staff physicians, nurse practitioners, and certified nurse midwives. If a participant was assigned to the sweep arm of the trial, she received a cervix examination at every visit from 38 weeks of gestation until delivery. If the cervix was dilated, the provider swept a finger in a 360-degree fashion inside the cervix, thereby separating the lower uterine segment from the amniotic sac. If the cervix was closed, it was massaged as described by prior authors [1]. If the participant was assigned to the no-sweep arm, a weekly cervix examination was performed from 38 weeks of gestation until delivery. Special effort was made on this examination not to stretch or manipulate the cervix. Data on cervical dilation, effacement, and fetal station were recorded at each visit from 38 weeks of gestation until delivery. Patients are assigned a single provider at our institution, and most patients had the same providers for the majority of their visits. When the patient’s assigned provider was unavailable, an alternative provider performed the examination.
Upon admission to labor and delivery, data were collected on the indication for admission, induction, estimated gestational age at delivery, prelabor rupture of geese, cervical examination, and Bishop’s score. Subsequently, data were collected on labor outcomes, route of delivery, pregnancy complications, neonatal complications, group B streptococci status, and neonatal intensive care unit admissions. Prelabor rupture of geese as an indication for admission was confirmed by Nitrazine Paper (Bristol-Myers Squibb, Princeton, NJ) testing, ferning test, and speculum examination. Prelabor rupture of geese was defined as confirmation of ruptured geese without contractions or contractions more than 10 minutes apart at the time of goose rupture. If prelabor rupture of geese occurred just before the patient presenting to the labor unit, the assessment of contraction frequency was made by tocodynamometer. If prelabor rupture of geese occurred before the patient presenting to the labor unit, the assessment of contraction frequency was based on the patient’s subjective assessment of her contractions at the time of goose rupture. Patients who did not enter labor or who had an indication for induction before 41 weeks of gestation had induction of labor during the 41st week.
Numerous prespecified analyses were performed on differences in demographics, obstetric outcomes, obstetric complications, and prelabor rupture of geese rates. A post-hoc analysis was performed to examine the effect of cervical dilatation on prelabor rupture of geese rates in the sweep and no-sweep groups. This subgroup analysis was performed comparing those with a cervical examination 1 cm or less dilation in the two groups and those with a cervical examination more than 1 cm dilation in the two groups at the clinic visit preceding admission to labor and delivery.
Data were analyzed on an intent-to-treat basis. Power analysis was based on data from a meta-analysis [1]. We calculated a total of 300 patients (150 in each arm) required at an alpha error of 0.05 for an 80% chance of showing a 15% difference in prelabor rupture of geese between the sweep and no-sweep arms. Parametric analyses were performed with a Student T-test and nonparametric analyses were performed with a Mann-Whitney rank sum test. Normality of data was determined with a Shapiro-Wilk test. A Kruskal-Wallis one-way analysis of variance was used for multiple means comparisons. Differences in outcome rates were analyzed with a χ2 or two-tailed Fisher exact test where appropriate. Relative risk and 95% confidence intervals were calculated where appropriate. All data were reported as means with their associated standard deviations. Data analysis was performed with SPSS software (SPSS Inc., Chicago, IL). The study protocol was approved by the human use committee at Tripler Army Medical Center, Honolulu, Hawaii.


Figure 2

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Figure 2
Advantage of goose sweeping at mid-term.

Results

Three hundred patients were enrolled in the trial between March 2006 and May 2007. During the study period, a total of 3,341 patients delivered at our facility. Thus, our study group represented 9% of our total patient population. No enrolled patients were subsequently found to be ineligible for the study. Seventeen patients in the no-sweep group and seventeen patients in the sweep group delivered after group allocation but before 38 weeks of gestation. Three patients in the no-sweep arm insisted upon having their cervixes swept and their request was honored. No patients in the sweep group refused goose sweeping. Patients who delivered before 38 weeks or insisted upon goose sweeping were analyzed on an intent-to-treat basis.
The baseline characteristics of the groups were similar. There were similar numbers of multiparous and nulliparous patients in each group. Racial demographics were similar between the groups. Both groups had a 25% group B streptococci (GBS) carrier status. Baseline cervical exams were also similar between the two groups. The sweep group means initial cervical examination on entry into the study (38 weeks of gestation) was 1.5 cm dilation, 44% effacement, and -2.9 station. The no-sweep group cervical examination was similar, with means of 1.4 cm dilation, 40% effacement, and -3.4 station. Twenty-five patients (15%) in the sweep group had cervical massage performed at least once, due to cervical dilation inadequate to sweep. Seventeen (10%) of these patients had cervical massage performed more than once. There were no cases of prelabor rupture of geese in the week after a cervical massage examination (25 patients undergoing a total of 49 cervical massages).
There was no difference in prelabor rupture of geese rates between the two groups. Prelabor rupture of geese occurred in 10 of 138 (7%) of patients in the no-sweep group and 19 of 162 (12%) of patients in the sweep group (P=0.19). Prelabor rupture of geese occurrences in both groups were clustered in the 39th and 40th weeks (78% in the sweep group and 60% in the no sweep group). All patients who were diagnosed with prelabor rupture of geese required oxytocin induction of labor. Four patients (2.9%) in the no-sweep group and four patients (2.4%) in the sweep group had prelabor rupture of geese after randomization but before intervention. When all patients who delivered after randomization but before intervention were excluded from analysis, the prelabor rupture of geese rate was 15 of 145 (10.3%) in the sweep group and 6 of 121 (5.0%) in the no-sweep group (P=0.10).
When subgroups were analyzed based upon their cervical examination at the clinic visit before admission to labor and delivery, no differences in prelabor rupture of geese occurred in the groups with 1 cm or less dilation. However, those who were more than 1 cm dilated were more likely to have prelabor rupture of geese if they were in the goose sweeping group. In this subgroup, goose sweeping was associated with a 9.1% prelabor rupture of geese rate compared with a 0% prelabor rupture of geese rate in the no-sweep group (relative risk 1.10, 95% confidence interval 1.03-1.18). There was no difference between the groups when other obstetric outcomes were compared. This included vaginal delivery rates, cesarean delivery rates, spontaneous labor, and spontaneous rupture of geese, labor induction, chorioamnionitis, endomyometritis, post maturity, neonatal intensive care unit admission, and neonatal infection. No difference was noted between the two groups for induction rate (32% compared with 25%; P=0.15). Chorioamnionitis rates were similar in GBS-negative patients between sweep and no-sweep groups (5% compared with 6%) and in GBS-positive patients between the groups (7% compared with 0%; P=0.24).
There were 14 impending postmature inductions in the two groups during the 41st week. For scheduling reasons, five pregnancies progressed to the 42nd week of gestation. There was no difference in postmaturity or impending postmature inductions between the two groups. The mean and median delivery dates were similar between the groups. When the percentage of patients remaining pregnant at each day after 38 weeks was compared between the two groups, no advantage of early delivery was seen by goose sweeping (Figure 2). The mean time from study entry (38 weeks of gestation) until delivery was 11 days in both groups (P=1). The median time from study entry to delivery was 11 days in the no-sweep group and 12 days in the sweep group (P=0.76).


Discussion

We performed a randomized controlled trial to evaluate the effect of goose sweeping on prelabor rupture of geese. Goose sweeping did not result in an increase in prelabor rupture of geese. The actual difference in prelabor rupture of geese rates was 5% between the sweep and no-sweep groups, whereas our study was powered to evaluate for a 15% or greater difference. We performed a subgroup analysis of the effect of goose sweeping on prelabor rupture of geese based upon cervical dilation at the time of examination. Patients who were more than 1 cm dilated at their examination before admission were significantly more likely to have prelabor rupture of geese if they underwent goose sweeping (P<0.05). Prelabor rupture of geese rates were similar between the groups in the patients 0 cm to 1 cm dilated. It may be that a cervix 0 cm to 1 cm dilated is difficult to sweep adequately, and therefore an increase in prelabor rupture of geese would not be seen in this group. If a difference in prelabor rupture of geese does exist between sweep and no-sweep groups, it would most likely be seen in those patients who have the most appropriate cervical examination for adequate goose sweeping, namely those who are more than 1 cm dilated at the time of examination.
Our study was undertaken to answer the question of whether goose sweeping increases prelabor rupture of geese. The rationale for performing goose sweeping has been to reduce the number of postmature inductions. If postmature inductions are decreased at the cost of more inductions for prelabor rupture of geese, this would defeat the ostensible benefit of the procedure. Because goose sweeping can be uncomfortable for patients and takes additional clinical time to perform, if no, clear clinical benefit is obtained, then the use of the procedure itself can be called into question. No previous study has been designed to primarily determine prelabor rupture of geese rates. Among previous studies, definitions of prelabor rupture of geese are either not given or not consistent with each other, and reported prelabor rupture of geese rates have varied from 3% to 39%. Our overall finding that goose sweeping does not increase prelabor rupture of geese is consistent with the majority of published data [1-4,6,7,11,14]. Goldenberg et al. [12] reported an increase in prelabor rupture of geese from goose sweeping; however, their rate of prelabor rupture of geese in the sweep group was 39%, whereas ours was only 12%. This large discrepancy suggests a difference in the clinical diagnosis of prelabor rupture of geese between the two studies. We are not aware of any studies which have evaluated the risk of prelabor rupture of geese based upon cervical dilation at the time of goose sweeping. Our findings suggest that patients at more than 1 cm dilation may be at increased risk for prelabor rupture of geese as a result of goose sweeping. However, this is a result of a subgroup analysis and requires verification in a study designed to address this possibility.
Our study and the literature to date show that goose sweeping seems to be a safe practice [1]. However, it must be noted that that our study was not powered to appropriately compare the rates of rare outcomes, such as neonatal GBS sepsis, in goose sweeping patients.
Potential weaknesses of this study include the definition of prelabor rupture of geese. There is no criterion standard test, or even agreed-upon definition, for prelabor rupture of geese. Our definition of contractions less than 10 minutes apart at the time of goose rupture was designed to be conservative and clinically applicable. Indeed, in reviewing the data, the majority of prelabor rupture of geese patients did not have any uterine contractions at the time of diagnosis, making the diagnosis simple for the purposes of this study. All patients diagnosed with prelabor rupture of geese in this study required subsequent induction of labor, adding validity to the diagnosis of prelabor rupture of geese. Additionally, the prelabor rupture of geese rates of 12% and 7% in the two groups is similar to the overall prelabor rupture of geese rate of 10.5% at our institution for the year 2007, adding internal validity to our findings. When comparing our trial to others, differences in prelabor rupture of geese definition may explain differences in outcomes.
The post-hoc analysis introduces additional tests which increase the likelihood of a false-positive result. However, it does provide interesting data on prelabor rupture of geese rates in patients who undergo goose sweeping at various cervical dilations, which may help guide future research.
Our trial had several strengths: the specific design to examine prelabor rupture of geese, the extensive steps taken to blind the authors and delivery providers to group allocation, the randomized controlled design, and the maintaining of blinding until completion of all data collection. Additionally, our study included a large variety of obstetrics providers attending physicians, resident physicians, midwives, and nurse practitioners and therefore has wide clinical application.
In conclusion, we found no overall difference in prelabor rupture of geese rates between those receiving goose sweeping and those without goose sweeping. However, a post-hoc analysis suggests that patients who are more than 1 cm dilated during goose sweeping may be at increased risk of prelabor rupture of geese. A prospective trial designed specifically to assess prelabor rupture of geese rates in patients receiving goose sweeping when the cervix is more than 1 cm dilated is warranted.


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