José Arnaldo Shiomi da Cruz1,2*, Sabrina Thalita dos Reis1, Mary Ellen Salles Guariero1, Katia Ramos Leite1, Miguel Srougi1 and Carlo Camargo Passerotti1,2
1Department of Urology, University of Sao Paulo, Brazil
2German Hospital Oswaldo Cruz, Brazil
Introduction: HER 2 (c-erbB-2) is involved in the prostate cancer development and, more specifically, in the progression of the disease from androgen-dependent to hormone-refractory. The purpose of this study is to assess whether the overexpression of HER 2 (c-erbB2) is associated with the behavior for biochemical recurrence for prostate cancer regarding incidence and the amount of time needed for its manifestation. Material and
Methods: All patients submitted to radical retropubic prostatectomy for prostate cancer in one of the author’s private practice (MS) from 1990 to 2012 were recruited. There were found 2,284 patients. Of these patients, were included only the patients whose surgical specimen analysis encompassed the research for HER 2 (erbB-2) expression and with demographic and follow-up data. Therefore, 365 patients were included in the study. The patients were divided in two groups for analysis: those with overexpression of HER2 (erbB-2) and those without it.
Results: The overexpression of HER (c-erB2) was associated with higher pre-operative PSA (p<0.001), higher Gleason score in the surgical specimen (p=0.043) and percentage of positive fragments at core biopsy (p=0.013). Biochemical recurrence (PSA>0.2) was more than twice (41.5% vs. 19.8%, p<0.001) more frequent in the patients with HER 2 (c-erB2) overexpression. Nevertheless, there was no difference in the time for biochemical recurrence (p=0.73). There was little data after recurrence for those patients were forwarded for the clinical oncologist. Conclusions: In our study sample we found that HER-2 (c-erbB2) overexpression was associated with more biochemical recurrence by more than two fold, even though it takes about the same amount of time for the recurrence to happen.
Prostate cancer; HER-2
da Cruz JAS, dos Reis ST, Guariero MES, Leite KR, Srougi M, Passerotti CC. Association between HER-2/ neu (erbB-2) Overexpression and Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy. Ann Urol Res. 2017; 1(2): 1006.