Raskin Shakya1*#, Hong-Liang Xu2#, Yu-Cheng Lin1, Bin-Bin Ma1, Yi-Ming Qi1, Ying-Juan Li3, Liu Shi1,4, Fei Hu5, Chen Wang1, Hui Chen1 and Yun-Feng Rui1,2,6*
1Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, PR China
2Department of Orthopaedics, Xishan People’s Hospital, PR China
3Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, PR China
4Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, PR China
5Department of Orthopaedics, Xinjiang Yili Kazak Autonomous Prefecture Hospital of traditional Chinese Medicine, China
6China Orthopedic Regenerative Medicine Group (CORMed), China
Huge amount of blood loss has been a big problem in the Total Hip Arthroplasty (THA). Several methods are being used to reduce intra operative or post-operative blood loss. Homologous blood transfusion is mostly preferred to compensate blood loss. But Tranexamic Acid (TXA) has been shown to be effective in reducing blood loss and lessen transfusion requirement in total hip replacement surgery. The main aim of the study is to find out the effectiveness and safety of TXA given pre and post-operatively to reduce the blood loss during a Hip replacement surgery. This article reviews the evidences provided by the different authors in their research papers. The review also discusses the appropriate dose and the form of application of TXA. The article states the need of protocol use of TXA in THA, in definite doses and the definite forms of administrations according to the safety concerns. The research articles were searched using the search engines such as PubMed, MEDLINE, Cochrane database, Ovid database, Embase database, Science Direct database, etc. The related articles which met our criteria were sorted and reviewed. The article related to use of TXA in THA in any form and any amount of doses, published after 2000 AD till date, in English were selected.
Tranexamic Acid; Total Hip Arthroplasty; Blood loss; Method of administration; Venous thromboembolism
Shakya R, Xu H-L, Lin Y-C, Ma B-B, Qi Y-M, Li Y-J. Application of Tranexamic Acid in Total Hip Arthroplasty: Current Evidences. Ann Trauma Acute Care. 2017; 1(1): 1001.