Ann Trauma Acute Care | Volume 1, Issue 1 | Research Article | Open Access

Application of Tranexamic Acid in Total Hip Arthroplasty: Current Evidences

Raskin Shakya^1*#, Hong-Liang Xu^2#, Yu-Cheng Lin¹, Bin-Bin Ma¹, Yi-Ming Qi¹, Ying-Juan Li³, Liu Shi^1,4, Fei Hu⁵, Chen Wang¹, Hui Chen¹ and Yun-Feng Rui^1,2,6*

¹Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, PR China
²Department of Orthopaedics, Xishan People’s Hospital, PR China
³Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, PR China
⁴Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, PR China
⁵Department of Orthopaedics, Xinjiang Yili Kazak Autonomous Prefecture Hospital of traditional Chinese Medicine, China
⁶China Orthopedic Regenerative Medicine Group (CORMed), China

^*Correspondance to: Raskin Shakya 

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Abstract

Huge amount of blood loss has been a big problem in the Total Hip Arthroplasty (THA). Several methods are being used to reduce intra operative or post-operative blood loss. Homologous blood transfusion is mostly preferred to compensate blood loss. But Tranexamic Acid (TXA) has been shown to be effective in reducing blood loss and lessen transfusion requirement in total hip replacement surgery. The main aim of the study is to find out the effectiveness and safety of TXA given pre and post-operatively to reduce the blood loss during a Hip replacement surgery. This article reviews the evidences provided by the different authors in their research papers. The review also discusses the appropriate dose and the form of application of TXA. The article states the need of protocol use of TXA in THA, in definite doses and the definite forms of administrations according to the safety concerns. The research articles were searched using the search engines such as PubMed, MEDLINE, Cochrane database, Ovid database, Embase database, Science Direct database, etc. The related articles which met our criteria were sorted and reviewed. The article related to use of TXA in THA in any form and any amount of doses, published after 2000 AD till date, in English were selected.

Keywords:

Tranexamic Acid; Total Hip Arthroplasty; Blood loss; Method of administration; Venous thromboembolism

Citation:

Shakya R, Xu H-L, Lin Y-C, Ma B-B, Qi Y-M, Li Y-J. Application of Tranexamic Acid in Total Hip Arthroplasty: Current Evidences. Ann Trauma Acute Care. 2017; 1(1): 1001.