Ann Stem Cell Res Ther | Volume 6, Issue 1 | Mini Review | Open Access

Cannabidiol Induces Immunomodulation by the Enhancing and Activation of CB2 Receptor Reducing Murine aGVHD

Barbara Betonico Berg1,2 and Marina Gomes Miranda e Castor1,2*

1Department of Pharmacology-ICB, LAFACI, Brazil 2Department of Physiology and Pharmacology-ICB, Federal University of Minas Gerais, Brazil

*Correspondance to: Marina Gomes Miranda e Castor Romero 

Fulltext PDF

Abstract

CBD treatment, through CB2 activation, increases Tregs in the intestine and reduces cytokine/ chemokine release the treatment also increases CD8+ cells maintaining the GVL effect. Altogether, these factors contribute to the protection of target organs and increase in host survival.

Keywords:

Hematopoietic stem cells; Cannabidiol; Immunomodulation; Graft-versus-host disease

Citation:

Berg BB, Miranda e Castor MG. Cannabidiol Induces Immunomodulation by the Enhancing and Activation of CB2 Receptor Reducing Murine aGVHD. Ann Stem Cell Res Ther. 2022; 6(1): 1042..

Subscribe to Our Newsletter