Department of Anatomy, College of Medicine, King Saud University and King Khalid University Hospital, Saudi ArabiaFulltext PDF
Regenerative medicine is an emerging new medical discipline that aims at treating chronic, age related degenerative diseases e.g. diabetes, Parkinson’s disease, osteoporosis, osteoarthritis, using stem cells. Complicated and non healed fractures represent a major health care problem that not only affecting elderly patients with osteoporosis but also young person’s exposed to traumatic injuries due to accidents and in patients with cancers e.g. osteosarcoma or metastatic cancers resulting in bone destruction. Regenerative medicine can provide a novel approach for enhancing bone regeneration. It is known that disturbances of the balance between osteogenesis and adipogenesis lead to metabolic diseases such as osteoporosis. Cannabinoid receptors and their ligands have been involved in the regulation of various physiological processes and have become the focus of cell therapy and a potential method therapy for significant health concern like osteoporosis. Thus, their role aimed at altering the differentiation direction of Mesenchymal Stem Cells (MSCs) to promote osteoblast differentiation and inhibit adipocyte differentiation. Cannabinoid receptor type 2 signaling using selective receptor compounds encourages the expression of osteogenic genes and enhances mineralization.
Mahmood A. Role of Cannabinoid Receptors CB1 & CB2 during Osteoblast Differentiation of Human Mesenchymal Stem Cells. Ann Stem Cell Res Ther. 2020; 4(1): 1038..