Ann Stem Cell Res Ther | Volume 1, Issue 1 | Research Article | Open Access

Adverse Events after Infusion of Cryopreserved and Non Cryopreserved Hematopoietic Progenitor Cells from Different Sources

Pilar Solves*, Maribel Penalver, Maria Jose Arnau, Anakira Munoz, Marga Navarro, Lydia Navarro, Alba Perez, Inmaculada Vaquero, Ines Gomez, Guillermo Francisco Sanz, Miguel Angel Sanz and Nelly Carpio

Department of Hematology and Hemotherapy, Hospital Universitario I Politécnico La Fe, Spain

*Correspondance to: Pilar Solves 

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Abstract

Hematopoietic Stem Cell (HSC) transplantation from different sources is mainly used for treatment of life-threatening hematopoietic malignancies. Infusion of thawed hematopoietic HSC may produce a variety of Adverse Events (AEs) usually mild to moderate. The most frequent AEs reported include nausea, vomiting, headache, diarrhoea, flushing, chills, and fever. Our objective was to analyse in a prospective way the AEs occurring in our Transplantation Unit and related to the infusion of HSC from different sources and in different conditions. We have prospectively collected data on adverse events occurring after 126 infusions of HSC performed in our Transplantation Unit between January 2016 and December 2016. Autologous peripheral blood and cord blood HSC were Cryopreserved using DMSO. Before infusion the grafts were automatically washed with a solution containing albumin, Acid Citrate Dextrose (ACD) and dextran. Allogeneic peripheral blood was infused shortly after collection. For a 1-year period 126 patients received high dose chemotherapy followed by infusion of HSC grafts: 60 patients received thawed and washed autologous peripheral blood HSC, 52 patients received allogeneic non-manipulated HSC and 14 patients received thawed and washed umbilical cord blood grafts. Infusion related AEs were reported in 41 patients (32.5%): 39 were graded 1, and two were graded 2. Median time of AEs appearance was 5 hours after infusion. More than one AE was reported in 26 patients (20.6%). Patients who suffered an AE were older than patients who did not (p =0.059). Despite the HSC grafts washing, AEs after infusion occurs in a significant number of patients.

Citation:

Solves P, Penalver M, Arnau MJ, Munoz A, Navarro M, Navarro L, et al. Adverse Events after Infusion of Cryopreserved and Non Cryopreserved Hematopoietic Progenitor Cells from Different Sources. Ann Stem Cell Res Ther. 2018; 1(1): 1004.

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