Latest Articles

Review Article

A Review of Isoagglutinin Change Kinetics in ABO Incompatible Hematopoietic Stem Cell Transplantation

Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) is a treatment modality for highrisk hematological malignancies that has considerably evolved over time.

Published 26 Nov, 2018


Explaining Allogeneic Hematopoietic Transplant to Patients through Analogies: For Practicing Oncologists

Comprehending Allogeneic Hematopoietic Stem Cell Transplant (AHCT) can be a daunting task for patients.

Published 29 Oct, 2018

Clinical Image

Extracellular Vesicles Derived from Mesenchymal Cells for Wound Healing: In Vitro Scratch Assay

Rabbit skin fibroblasts (1 × 105/well) were plated in Cytoselect 24 well wound healing assay (DBA, Milano, Italy) and incubated at 37°C, 5% CO2.

Published 30 Aug, 2018

Research Article

A Promotional Role of BDNF in Pluripotent Stem Cells Neural Differentiation via Wnt/ β -Catenin and ERK/MAPK Signaling Pathways

Objective: To investigate the role of Wnt/ β -catenin and ERK/MAPK signaling pathways in Brain-Derived Neurotrophic Factor (BDNF) Induction of Pluripotent Stem Cells (iPSCs) differentiation into Neural Stem Cells (NSCs).

Published 20 Aug, 2018


Human Muscle Stem Cells and the Effect of Aging

The skeletal muscle tissue is able of maintaining its mass during adulthood thanks to the role played by myogenic precursors, activated under certain stimuli.

Published 27 Jun, 2018


The Future Need for Massive Expansion of Stem Cell Numbers for Stem Cell Therapies

When Stem Cell (SC) therapies ultimately become standard therapies, the estimated number of stem cells needed will be incredibly large.

Published 25 Jun, 2018

Case Report

Posaconazole-Induced Uncontrolled Hypertension in Allogeneic Hematopoietic Transplant

Posaconazole is a triazole antifungal agent with a broad-spectrum antifungal activity; it is frequently used as prophylaxis and treatment of fungal infections.

Published 18 Jun, 2018

Review Article

Immune Properties of Human Dental Pulp Stem Cells and Interactions with the Immune System

Dental Pulp Stem Cells (DPSCs) are mesenchymal stem cells well known by the scientific community thanks to the studies about their regenerative properties.

Published 21 May, 2018


The Transitioning from Stem Cells to Stem Cell-Derived Exosomes for Treatment of Neurodegenerative Conditions

Arguably, the therapeutic application of stem cells is one of the most exciting advancements in the field of neurodegenerative diseases.

Published 27 Apr, 2018


Development of Pharmacological Agents for the Activation and Directional Differentiation of Resident Stem Cells in Organs and Tissues

One of the most promising resources of the body for restoring the myocardium after ischemic damage and optimizing the functions of the cardiac muscle during aging are resident Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells (CSC, BM MSC).

Published 26 Apr, 2018


Mesenchymal Stem Cell Spheroids Therapy

Mesenchymal Stem Cells (MSCs) hold great promise in treating degenerated tissues or organs because they are capable of multi-lineage differentiation and self-renewal.

Published 26 Apr, 2018

Short Communication

Physiologically-Relevant Cellular Models for Biomarkers and Drug Discovery

Dr. Peter Stern, senior editor at Science, recently wrote that “these are exciting times for neuroscience” and I could not agree more because, for the first time, one of the big questions in our field may be answered soon: “Where are the cures?” with the advent of Human Induced Pluripotent Stem cells (hiPS), “cures” for Central Nervous System (CNS) ailments appear to be around the corner.

Published 26 Apr, 2018

Review Article

GFI1B in Stem Cell Biology and Cancer

GFI1B was identified by sequence homology with the oncogene GFI1 (Growth Factor Independence 1).

Published 31 Mar, 2018

Research Article

Role of Sparc as a Prognostic Factor in Pancreatic Tumors

Background: Pancreatic adenocarcinoma is one of the most aggressive solid neoplasms.

Published 31 Mar, 2018

Case Report

Vancomycin: A Friend or a Foe- A Case of Life Threatening Thrombocytopenia Induced by Vancomycin

Thrombocytopenia is a rare side effect of vancomycin, an antibiotic that is widely used to treat Grampositive bacterial infections particularly Methicillin-Resistant Staphylococcus Aureus (MRSA) infection.

Published 30 Mar, 2018

Letter to the Editor

The Effect of Rasburicase on the Labile Fraction of Hemoglobin A1c During High Performance Liquid Chromatography

We describe an unusual and previously unreported effect on High Performance Liquid Chromatography (HPLC) trace caused by rasburicase, the recombinant form of urate oxidase.

Published 26 Feb, 2018


Mesenchymal Stem Cells: Do We Believe Their Clinical Potential?

Mesenchymal Stem Cell (MSC) is a multipotent stem cell derived from various adult tissues including bone marrow, adipose tissue, umbilical cord blood, umbilical cord, dental pulp, etc. and be able to differentiate into different cell types and culture efficiently in vitro.

Published 26 Feb, 2018

Case Report

Confusing Presentations of Hodgkin Lymphoma

The disease we today call Hodgkin lymphoma was named after Thomas Hodgkin, a physician at Guy’s Hospital in London who in the 1830’s did autopsies on 7 patients who died of an illness characterized by progressive lymphadenopathy.

Published 26 Feb, 2018


iPS Cell Generation: Current and Future Challenges

The ground breaking discovery of reprogramming somatic cells to generate induced Pluripotent Stem (iPS) cells more than a decade ago has revolutionized stem cell research attracting immense global attention [1].

Published 30 Jan, 2018


Better Selection of Grafts Reduces Significantly Transfusion Requirements in Patients Undergoing Umbilical Cord Blood Transplantation

Hematopoietic Stem Cell Transplantation (HSCT) is a common treatment for patients affected by hematologic malignancies and congenital diseases of the immune system [1].

Published 29 Jan, 2018


Progress in Stem Cell Research Opens New Avenues for Degenerative Diseases

Stem cells have the unique ability to divide continuously. They are found in various parts of our body, from the early stages of human development to adulthood.

Published 03 Jan, 2018

Research Article

Adverse Events after Infusion of Cryopreserved and Non Cryopreserved Hematopoietic Progenitor Cells from Different Sources

Hematopoietic Stem Cell (HSC) transplantation from different sources is mainly used for treatment of life-threatening hematopoietic malignancies.

Published 03 Jan, 2018


Immune-Inflammatory Modulation as the Therapeutic Strategy of Stem Cell Therapy for Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease with no cure.

Published 20 Nov, 2017


New Technologies for Solving Actual Problems of Biomedicine

This year marks the 10th anniversary of the publication of works on the production of induced human pluripotent stem cells (hiPSC) [1,2].

Published 04 Jun, 2017


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