Ann Short Rep | Volume 2, Issue 4 | Research Article | Open Access
Yanhong L*, Liang G, Yuan-zheng L, Jianing K, Zhang H and An-ping Y
Department of Neonatology, Zhengzhou People's Hospital, China
Fulltext PDFObjectives: The aims of this study were to assess the efficacy of less invasive surfactant administration technique in different times under duo positive airway pressure ventilation in preterm infants born at 28 to 34 weeks. Methods: A total of 58 preterm infants with gestational ages between 28 to 34 weeks diagnosed with NRDS in Zhengzhou People's Hospital, from June 2017 to June 2018 were randomly divided into early LISA Group (30 cases) and a Remedial Group (28 cases) by adopting random number table method. In the early LISA group, the infants were treated with immediately duo positive airway pressure ventilation and a thin stomach tube was inserted through the vocal cords then infused Pulmonary Surfactant (PS) into the lung. In the remedial LISA group, the infants were treated with immediately duo positive airway pressure ventilation and, when they were progressive exacerbation of dyspnea, then a thin stomach tube was inserted through the vocal cords then infused Pulmonary Surfactant (PS) into the lung. Comparisons were made between the two groups as for the proportions of mechanical ventilation, length of hospital stay, hospitalization expenses, pneumothorax, pneumonia, Bronchial Pulmonary Dysplasia (BPD), and the incidence of Intracranial Hemorrhage (ICH). Results: Compared with the differences between the 2 groups in the need of mechanical ventilation, length of hospital stay, and complications such as pneumothorax, pneumonia, BPD and ICH, there were no statistical differences (all P>0.05). The hospitalization expenses of the remedial group were significantly lower than those of the early application group (P<0.05). Conclusion: LISA remedial application technology on therapy RDS is feasible and can significantly reduce the hospitalization expenses. LISA remedial application technology does not increase the proportions of mechanical ventilation, pneumothorax, pneumonia, BPD and ICH.
Less invasive surfactant administration; Respiratory distress syndrome; Premature
Yanhong L, Liang G, Yuan-zheng L, Jianing K, Zhang H, An-ping Y. Clinical Observation on Remedial Less Invasive Surfactant Administration Technique Under Duo Positive Airway Pressure Ventilation in Treating Preterm Infants with Respiratory Distress Syndrome. Ann Short Reports. 2019; 2: 1045.