Ann Short Rep | Volume 2, Issue 3 | Case Report | Open Access

Meropenem at Recommended Dose Can Cause Potential Risk for Seizure in Hemodialysis Patient

Abdullah Al-Hwiesh^1*, Amani Alhwiesh¹, Eman Fathi², Fadwa Mohamed², Manar Elsayed², Jamielou Almazan², Abdullah Alrashidi², Fatimah Aldehiam², Azeeza Aldwaihi², Saad Alqhtani², Hussin Alsharani² and Nadia Aluauda³

¹Department of Nephrology, King Fahd Hospital of the University, Saudi Arabia ²Department of Nephrology, Security Force Hospital Damam, Saudi Arabia ³Department of Nephrology, Damman Central Hospital, Saudi Arabia

^*Correspondance to: Abdullah Al-Hwiesh 

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Abstract

Dosage adjustment of meropenem is usually recommended in hemodialysis patient and about 30% of meropenem is cleared during regular hemodialysis session. However, most of published trials excluded patients on regular hemodialysis. Little is known about the exact dosage of meropenem to ovoid central nervous system toxicity. Here we report a 65 year old Saudi lady known case of end stage renal failure on regular hemodialysis was admitted due to pyelonephritis and was started on meropenem as recommended dose, developed tonic clonic convulsion after seventh dose of meropenem and the seizure completely aborted after discontinuation the offending drug. The recommended dosage of 500 mg daily in hemodialysis patients may be still too high in particularly Asians patient, owing to their relative small body mass index.

Keywords:

Meropenem; Seizure; ESRD; Hemodialysis

Citation:

Al-Hwiesh A, Alhwiesh A, Fathi E, Mohamed F, Elsayed M, Almazan J, et al. Meropenem at Recommended Dose Can Cause Potential Risk for Seizure in Hemodialysis Patient. Ann Short Reports. 2019; 2: 1043.