Ann Pharmacol Pharm | Volume 1, Issue 1 | Review Article | Open Access

Facile Synthesis of NaMN, NaAD and Derivatives

Marci Wood and Yana Cen^*

Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, USA

^*Correspondance to: Yana Cen 

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Abstract

Simple and efficient syntheses of NAD⁺, an important biological cofactor, and its precursors have been limited to amido versions. Here we report the novel synthesis of two previously overlooked NAD+ precursors, NaMN and NaAD, using a common intermediate, ethyl nicotinate riboside (O-ethyl-NaR). In addition, these synthetic metabolites were shown to be substrates for NAD⁺ biosynthetic enzymes and were sufficient to increase cellular NAD⁺ levels.

Citation:

Wood M, Cen Y. Facile Synthesis of NaMN, NaAD and Derivatives. Ann Pharmacol Pharm. 2016; 1(1): 1007.