Lan-Chun Zhang1, Jia Liu1, Liu-Lin Xiong2* and Ting-Hua Wang1,2,*
1Department of Animal Zoology, Kunming Medical University, China
2Department of Anesthesiology, West China Medical Center, China
Complexions, as key presynaptic proteins in the progress of fast synchronous neurotransmitter release, play crucial roles in membrane fusion reactions and operate by associating with trimeric SNARE complexes. CPLX I/II act differentially influence on cognitive function of central nervous system disease, which exposed disruption of inhibitory synaptic terminals to trigger early cognitive impairment. Phenotype and preliminary application of CPLX1 knockout have been construction and application in animals. Although, CPLX1 located in presynaptic often forms SNARE complex to perform the physiological function, while, abnormal levels of CPLX1 appearances in neurodegenerative and psychiatric disorders could exhibit disrupted neurobehaviors. The critical role of CPLX1 in CNS is needed to widely recognize and utilize in neurodegenerative and psychiatric disorders.
Zhang L-C, Liu J, Xiong L-L, Wang T-H. The Critical Role of Complexion in the Central Nervous System. Ann Pharmacol Pharm. 2020;5(3):1182.