Ann Pharmacol Pharm | Volume 5, Issue 1 | Research Article | Open Access
Hua Jiang1,2, Jing-Ming Yang2 and Xiang-Cai Meng1*
1Heilongjiang University of Chinese Medicine, China
2Jinzhou Medical University, China
*Correspondance to: Xiang-Cai Meng
Fulltext PDFIntroduction: Unfavorable situations are key factors for elevation of herbal medicine quality. Plants produce a wide range of secondary metabolites to resist environmental stresses. As such, the aim of this study was to investigate whether Na2S2O4 stress can enhance the antipyretic, analgesic and anti-inflammatory effects of Radix Saposhnikoviae (RS).
Materials and methods: The roots of RS was sprayed with 3 mmol/l Na2S2O4 aqueous solution to wet and kept in a relative humidity of 90% for seven days and were named as Na2S2O4-stress-RS groups. After this processing, the contents and pharmacokinetic parameters of chromones in rats were measured by HPLC. The antipyretic, analgesic and anti-inflammatory effects were evaluated by pyretic animal model, hot plate test and paw edema model, respectively.
Results: Under Na2S2O4 stress, the content of chromone was significantly increased. And only cimifugin was found in plasma after RS and Na2S2O4-stress-RS were administered to rats, with a 25.8% increase of AUC0-24 h in the Na2S2O4-stress-RS groups. Likewise, more potent antipyretic, analgesic, and anti-inflammatory activities were also found in the latter.
Conclusion: Exposure of S. divaricata fresh roots to Na2S2O4 enhanced the quality and pharmacological actions of RS.
Radix saposhnikoviae; Na2S2O4; Pharmacokinetics; Pharmacological actions
Jiang H, Yang J-M, Meng X-C. Ectogenous Sodium Hyposulphite Enhanced Anti-Pyretic, Analgesic and Anti-Inflammatory Effects of Radix saposhnikoviae. Ann Pharmacol Pharm. 2020;5(1):1173.