Ann Pharmacol Pharm | Volume 2, Issue 10 | Short Communication | Open Access
Dar KB1,2, Bhat AH1,2, Amin S2, Anees S1,2, Zargar MA1, Masood A2 and Ganie SA1*
1Department of Clinical Biochemistry, University of Kashmir, Srinagar, India, 190006
2Department of Biochemistry, University of Kashmir, Srinagar, India, 190006
Cancer is a dreadful disease whose pathological roots lie deep inside the molecular pathways governing different biochemical process. Oncogenic cells divide abnormally in an uncontrolled manner and invade surrounding tissues/organs. Major Treatment strategies for cancer include chemotherapy, radiotherapy and surgery. Anti-cancerous chemical agents used for the treatment often met with serious repercussions. Herbal compounds capable of preventing or inhibiting the process of carcinogenesis represent a better option for obtaining effective anti-cancerous therapeutics. They act at multiple molecular targets involving DNA, enzymes, and cytoskeleton (microtubules) thereby blocking uncontrolled cell division. Taxol, vincristine, vinblastine, topotecan, camptothecin derivatives and etoposide derived from podophyllotoxin are the good examples of such compounds with proven anti-cancerous activity. Numerous natural products such as resveratrol, silvestrol and betulinic acid with promising antineoplastic activities are already in different phases of clinical trials. Over all there is direct medical application of herbal compounds to serve as chemical models or templates for the design, synthesis, and semi-synthesis of novel substances with potential to block cancer development and progression.
Oncogenes; Vincristine; Cancer; Clinical trial; Resveratrol
Dar KB, Bhat AH, Amin S, Anees S, Zargar MA, Masood A, et al. Herbal Compounds as Potential Anticancer Therapeutics: Current. Ann Pharmacol Pharm. 2017; 2(10): 1106.