Jiao Fuyong1*, Wang Juyan1, Feng Yingjun2, Zhang Sheng1, He Gaitao1 and Li Xiaohong1
1Department of Pediatrics, Children’s Hospital of Shaanxi Provincial People’s Hospital, China
2Department of Cardiology, Children’s Hospital Affiliated to Zhengzhou University, China
Objectives: To analyze the clinical features of children with Kawasaki Disease (KD) complicated with coronary artery aneurysm. Methods: The clinical data, laboratory examination, echocardiography and treatment of 17 children were retrospectively analyzed, who were diagnosed as coronary artery aneurysm in the 426 children with KD admitted to the Children's Hospital of Shaanxi Provincial People's Hospital from December 2013 to March 2018. Results: 1). The 17 (4.0%) children of the 426 KD children had coronary artery aneurysm. The mean age of onset was 2.0 ± 2.5 years old, and the incidence of coronary artery aneurysm in children aged 1 to 3 was the highest, accounting for 29.4%. The morbidity of males was significantly higher than that of females, and the ratio of males to females was 4:1. 2). In the distribution of coronary artery involvement, bilateral coronary artery involvement was the most common (47.1%), left coronary artery involvement alone accounted for 23.5%, and right coronary artery involvement alone accounted for 29.4%. 3). The time of finding coronary artery aneurysm was mostly within 2 weeks, and the average time of finding coronary artery aneurysm was 9.9 ± 4.4 days. 4). There was no significant difference between the degree of increase of ESR within 1 week and 2 weeks of the course of disease. After admission, the CRP level in 8 cases was significantly higher than normal, and in 10 cases became normal at discharge, the CRP level at discharge was significantly lower than that after admission. Coronary artery aneurysms were detected by echocardiography mostly within 2 weeks; coronary artery aneurysms appeared to be mostly affected by both coronary arteries; the proportion of primary infusion of gamma globulin was the highest. Conclusion: For males and 1 to 3 years old children with KD should be alert to the occurrence of coronary artery aneurysm, and Intravenous Gamma Globulin (IVIG) should be applied as soon as possible.
Kawasaki disease; Coronary artery aneurysm; Echocardiography; Mucocutaneous lymphnode syndrome
Fuyong J, Juyan W, Yingjun F, Sheng Z, Gaitao H, Xiaohong L. Clinical Analysis of Occurrence of Coronary Artery Aneurysm in 426 Children with Kawasaki Disease. Ann Pediatr Res. 2020;4(1):1032..