Ann Pediatr Res | Volume 4, Issue 1 | Research Article | Open Access
Sita Thakur, Kamal Singh*, Indu Saroha, Pankaj Sharma and Jyoti Sharma
Department of Obstetrics and Gynecology, Dr. Rajender Prasad Govt. Medical College Kangra, India
*Correspondance to: Kamal Singh
Fulltext PDFBackground: Induction of labor indicated when the benefit to either mother or fetus outweighs those of continuing pregnancy. Pharmacological methods used for induction includes oxytocin, prostaglandin (E1, E2) and mifepristone. However the ideal dose, route and frequency of administration of misoprostol and its perinatal outcome are still under investigation. Hence we
plan to do a comparative study between sublingual and vaginal misoprostol for inducing labor and its perinatal outcome.
Methodology: A prospective randomized interventional study was conducted on 70 pregnant women with singleton pregnancy with vertex presentation with period of gestation 37 to 42 weeks, who met the inclusion criteria and were willing to participate the study. They were explained in detail about the study on admission and were randomized into 2 groups: Group I (sublingual) and
Group II (vaginal). Bishop score at start of induction, doses required, mode of delivery, duration of different stages of labor and perinatal outcome of the women were recorded.
Results: Out of 35 women in each group, 29 women (82.8%) in both normal vaginal delivery, 1 woman in group I and 3 women in group II had instrumental delivery. Emergency cesarean section was done in 5 women (14.28%) in sublingual group and 3 women (8.57%) in vaginal group. Meconium passage was seen in 4 women (11.42%) in sublingual group as compared to 2 women (5.71%) in vaginal group. Non-reassuring fetal heart rate was noted in 2 women (5.71%) in sublingual group and 5 women (14.28%) in vaginal group. Though more number of women in vaginal group had not reassuring fetal heart rate, but the difference between two groups in relation to fetal side effects was not statistically significant (P=0.23).
Conclusion: Sublingual route represents a valid alternative to vaginal route with the advantage of convenience of administration. However, it appears to offer no additional clinical advantage over the vaginal route with respect to perinatal outcome. In view of limited sample size of our study, we cannot reach definitive conclusions in regard to the preference of sublingual or vaginal route of misoprostol administration for induction of labor and its perinatal outcome.
Prostaglandins; Oxytocin; Sublingual; Vaginal; PROM; Bishop score
Thakur S, Singh K, Saroha I, Sharma P, Sharma J. To Study the Perinatal Outcome in Women with Labor Induction by Sublingual vs. Vaginal Misoprostol. Ann Pediatr Res. 2020; 4(1):1030..