Sihui Ma1 and Katsuhiko Suzuki2*
1Graduate School of Sport Sciences, Waseda University, Japan
2Faculty of Sport Sciences, Waseda University, Japan
Toll-Like Receptors (TLRs) are a main target during inflammation and metabolic syndromes as receptors for inflammatory signaling molecules, and are named numerically from 1 to 13 in humans. It is believed that TLR4 plays a key role in exercise training-induced anti-inflammatory effects, whereas new evidence shows that TLR4 is the main receptor in fatty acid-induced inflammation. In this review, we summarized classical theories, and the new discovery in the field of fatty acidinduced inflammation through TLR4. Further, we highlight the anti-inflammation ability of exercise through regulating TLR4 as we try to acquire new clues for the treatment of metabolic diseases, and understand the regulatory effect of exercise.
Ma S, Suzuki K. Toll-like Receptor 4: Target of Lipotoxicity and Exercise- Induced Anti-inflammatory Effect? Ann Nutr Food Sci. 2018; 2(4): 1027.