Ann Neurol Surg | Volume 2, Issue 1 | Case Report | Open Access
Xinquang Qu and Huaxin Sheng
Department of Anesthesiology, Duke University Medical Center, USA
Department of Emergency and Critical Care Medicine, China Three Gorges University, China
*Correspondance to: Huaxin Sheng
Fulltext PDFStem cell transplantation is a promisng therapy for traumatic brain injury. Several phase I or IIa
clinical trials in recent years have indicated that this treatment is safe and feasible in patients.
Functional outcome was partially improved by this treatement. This review collected 112 preclinical
animal studies conducted from 1996 to 2017 and analyzed the key factors affecting the efficacy of
stem cell transplantation in treating traumatic brain injury (i.e., animal models, types and doses of
transplantated stem cells, intervetion routes, time window of treatment and period of follow up etc.),
and the associated action mechanism of transplanted stem cells (i.e., cell replacement, secretion of
neurotrophic factors and suppresion of inflammtion). The strategies for enhancing optimal stem
cell investigations are discussed and the data collected here would be of great value for planing
future clincal trials.
Stem cells; Traumatic brain injury; Preclinical; Transplantation
Qu X, Sheng H. Stem Cell Therapy for Traumatic Brain Injury: A Progress Update. Ann Neurol Surg. 2018; 2(1):
1008.