Ashikur Rahaman HN* and Shravana Kumar Chinnikatti
Department of Clinical Oncology, Enam Medical College & Hospital, BangladeshFulltext PDF
Introduction: Cervical cancer is the fourth most frequent cancer in women with an estimated 570,000 new cases in 2018 representing 6.6% of all female cancers. Approximately 90% of deaths from cervical cancer occurred in low and middle income countries. The high mortality rate from cervical cancer globally could be reduced through a comprehensive approach that includes prevention, early diagnosis, and effective screening and treatment programs. Objectives: This experimental study was carried out to compare the response and acceptable toxicity in concurrent chemo-radiotherapy and radiotherapy only in the treatment of cervical cancer. Materials and Methods: The study had conducted in the Department of Radiation Oncology, Enam Medical College Hospital, Savar, Dhaka in the Department of Radiation Oncology, National Institute of Cancer Research & Hospital (NICRH), Dhaka from July 2018 to June 2019. Type of Study: Experimental Study -Randomized Control Clinical Trail. Patients with carcinoma cervix attained at the Radiation Oncology Department of EMCH & NICRH during the study period had included in the study according to inclusion an exclusion criterion. Results: A total of 80 patients (40 patients in side A & 40 patients in side B) who have biopsy proven cervical carcinoma with no history of previous treatment were selected from the Department of Radiotherapy Enam Medical College Hospital, Savar, Dhaka and in the Department of Radiation Oncology, National Institute of Cancer Research & Hospital. All patients in both side received external beam radiation with 50Gy in 25 daily fractions over five weeks. Followed by three insertions of brachy therapy were given by 21Gy (one insertion per week for 7Gy). Patients in side A received injection Cisplatin 40mg/m2 in IV infusion on the first day of each treatment per week in addition to radiotherapy. In this study it was observed that a significant symptomatic improvement was found inside A after treatment than side B and no severe unwanted reaction was noted in most of the patients. Systematic toxicity developed in both groups and comparatively more in side A (chemo radiation) but that was not statistically significant and well managed with conservative treatment. Regarding performance status patients treated with concurrent chemoradiation showed better performance status than the patient treated with radiotherapy alone. Conclusion: In this study it was observed that patients of carcinoma cervix treated with concurrent chemo radiotherapy was effective for symptomatic improvement and suitable with acceptable toxicity for advanced cancer of the uterine cervix than those with radiation only.
Cervical cancer; Concurrent chemoradiotherapy; Efficacy; Toxicity
Ashikur Rahaman HN, Chinnikatti SK. A Comparative Study on Response and Toxicity of Concurrent Chemo- Radiotherapy and Radiotherapy Only in the Treatment of Cervical Cancer. Ann Med Medical Res. 2020;3:1026..